Critical Roles of IL-33/ST2 Pathway in Neurological Disorders

Interleukin-33 (IL-33) is an IL-1 family member, which exhibits both pro- and anti-inflammatory properties solely based on the type of the disease itself. Generally, IL-33 is expressed by both endothelial and epithelial cells and mediates its function based on the interaction with various receptors,...

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Detalles Bibliográficos
Autores principales: Abd Rachman Isnadi, Mohammad Faruq, Chin, Voon Kin, Abd Majid, Roslaini, Lee, Tze Yan, Atmadini Abdullah, Maizaton, Bello Omenesa, Ramatu, Osamah Ibraheem, Zaid, Basir, Rusliza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817350/
https://www.ncbi.nlm.nih.gov/pubmed/29507527
http://dx.doi.org/10.1155/2018/5346413
Descripción
Sumario:Interleukin-33 (IL-33) is an IL-1 family member, which exhibits both pro- and anti-inflammatory properties solely based on the type of the disease itself. Generally, IL-33 is expressed by both endothelial and epithelial cells and mediates its function based on the interaction with various receptors, mainly with ST2 variants. IL-33 is a potent inducer for the Th2 immune response which includes defence mechanism in brain diseases. Thus, in this paper, we review the biological features of IL-33 and the critical roles of IL-33/ST2 pathway in selected neurological disorders including Alzheimer's disease, multiple sclerosis, and malaria infection to discuss the involvement of IL-33/ST2 pathway during these brain diseases and its potential as future immunotherapeutic agents or for intervention purposes.

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