Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling

The antiparkinsonian ropinirole and pramipexole are D3 receptor- (D3R-) preferring dopaminergic (DA) agonists used as adjunctive therapeutics for the treatment resistant depression (TRD). While the exact antidepressant mechanism of action remains uncertain, a role for D3R in the restoration of impai...

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Detalles Bibliográficos
Autores principales: Collo, Ginetta, Cavalleri, Laura, Bono, Federica, Mora, Cristina, Fedele, Stefania, Invernizzi, Roberto William, Gennarelli, Massimo, Piovani, Giovanna, Kunath, Tilo, Millan, Mark J., Merlo Pich, Emilio, Spano, PierFranco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817382/
https://www.ncbi.nlm.nih.gov/pubmed/29531524
http://dx.doi.org/10.1155/2018/4196961

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