Cargando…

Molecular genetics and cellular events of K-Ras-driven tumorigenesis

Cellular transformation and the accumulation of genomic instability are the two key events required for tumorigenesis. K-Ras (Kirsten-rat sarcoma viral oncogene homolog) is a prominent oncogene that has been proven to drive tumorigenesis. K-Ras also modulates numerous genetic regulatory mechanisms a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jinesh, G G, Sambandam, V, Vijayaraghavan, S, Balaji, K, Mukherjee, S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817384/ https://www.ncbi.nlm.nih.gov/pubmed/29059163 http://dx.doi.org/10.1038/onc.2017.377

Ejemplares similares

Targeting K-Ras and apoptosis-driven cellular transformation in cancer
por: Godwin, Isha, et al.
Publicado: (2021)

A Central Role for Foxp3+ Regulatory T Cells in K-Ras-Driven Lung Tumorigenesis
por: Granville, Courtney A., et al.
Publicado: (2009)

Regulation of H-Ras-driven MAPK signaling, transformation and tumorigenesis, but not PI3K signaling and tumor progression, by plasma membrane microdomains
por: Michael, J V, et al.
Publicado: (2016)

Involvement of APC and K-ras mutation in non-polypoid colorectal tumorigenesis
por: Umetani, N, et al.
Publicado: (2000)

Inhibition of RAS-driven signaling and tumorigenesis with a pan-RAS monobody targeting the Switch I/II pocket
por: Wallon, Lauren, et al.
Publicado: (2022)

BTB-Zinc Finger Oncogenes Are Required for Ras and Notch-Driven Tumorigenesis in Drosophila
por: Doggett, Karen, et al.
Publicado: (2015)

Targeting RNA helicase DHX33 blocks Ras‐driven lung tumorigenesis in vivo
por: Wang, Xingshun, et al.
Publicado: (2020)

A Covalent Calmodulin Inhibitor as a Tool to Study Cellular Mechanisms of K-Ras-Driven Stemness
por: Okutachi, Sunday, et al.
Publicado: (2021)

Hyperglycemia Promotes K-Ras-Induced Lung Tumorigenesis through BASCs Amplification
por: Micucci, Carla, et al.
Publicado: (2014)

K-Ras stabilization by estrogen via PKCδ is involved in endometrial tumorigenesis
por: Koo, Kyoung-Hwa, et al.
Publicado: (2015)

Combined Inactivation of MYC and K-Ras Oncogenes Reverses Tumorigenesis in Lung Adenocarcinomas and Lymphomas
por: Tran, Phuoc T., et al.
Publicado: (2008)

ERK Dephosphorylation through MKP1 Deacetylation by SIRT1 Attenuates RAS-Driven Tumorigenesis
por: Kwon, Ok-Seon, et al.
Publicado: (2020)

miR-124 Inhibits Lung Tumorigenesis Induced by K-ras Mutation and NNK
por: Jin, Hua, et al.
Publicado: (2017)

K-Ras Binds Calmodulin-Related Centrin1 with Potential Implications for K-Ras Driven Cancer Cell Stemness
por: Manoharan, Ganesh babu, et al.
Publicado: (2023)

Prolonged sulforaphane treatment does not enhance tumorigenesis in oncogenic K-ras and xenograft mouse models of lung cancer
por: Kombairaju, Ponvijay, et al.
Publicado: (2012)

Role of autophagy in K-RAS- and B-RAF-driven lung cancers
por: White, Eileen
Publicado: (2014)

Sos-mediated cross activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis
por: Jeng, Hao-Hsuan, et al.
Publicado: (2012)

K-Ras Mediated Murine Epidermal Tumorigenesis Is Dependent upon and Associated with Elevated Rac1 Activity
por: Samuel, Michael S., et al.
Publicado: (2011)

The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis
por: Zhou, Chun, et al.
Publicado: (2012)

Cooperativity of Oncogenic K-Ras and Downregulated p16/INK4A in Human Pancreatic Tumorigenesis
por: Chang, Zhe, et al.
Publicado: (2014)

An ERK1/2‐driven RNA‐binding switch in nucleolin drives ribosome biogenesis and pancreatic tumorigenesis downstream of RAS oncogene
por: Azman, Muhammad S, et al.
Publicado: (2023)

Mutant Ras and inflammation-driven skin tumorigenesis is suppressed via a JNK-iASPP-AP1 axis
por: Al Moussawi, Khatoun, et al.
Publicado: (2022)

Efficacy of MEK inhibition in a K-Ras-driven cholangiocarcinoma preclinical model
por: Dong, Mingjie, et al.
Publicado: (2018)

JAK–STAT inhibition impairs K‐RAS‐driven lung adenocarcinoma progression
por: Mohrherr, Julian, et al.
Publicado: (2019)

SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer
por: Mazur, Pawel K., et al.
Publicado: (2014)

A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer
por: Zoranovic, Tamara, et al.
Publicado: (2018)

How do K-RAS-activated cells evade cellular defense mechanisms?
por: Lee, Y-S, et al.
Publicado: (2016)

Misshapen Disruption Cooperates with Ras(V12) to Drive Tumorigenesis
por: Kong, Du, et al.
Publicado: (2021)

p27(kip1) expression limits H-Ras-driven transformation and tumorigenesis by both canonical and non-canonical mechanisms
por: Pellizzari, Ilenia, et al.
Publicado: (2016)

Comparison of K-Ras and N-Ras Mutagenic Hot Spots for UVC Damage
por: Nair, Sindhu G., et al.
Publicado: (2019)

Killer K-Ras
por: Powell, Kendall
Publicado: (2006)

K-RAS Is…Complicated
por: Clark, Geoffrey J.
Publicado: (2023)

AAV9-mediated telomerase activation does not accelerate tumorigenesis in the context of oncogenic K-Ras-induced lung cancer
por: Muñoz-Lorente, Miguel A., et al.
Publicado: (2018)

K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder
por: Ahmad, Imran, et al.
Publicado: (2011)

Expression of Concern: Cooperativity of Oncogenic K-Ras and Downregulated p16/INK4A in Human Pancreatic Tumorigenesis
Publicado: (2019)

Germline and sporadic cancers driven by the RAS pathway: parallels and contrasts
por: Dunnett-Kane, V., et al.
Publicado: (2020)

Inactivation of RASA1 promotes melanoma tumorigenesis via R-Ras activation
por: Sung, Hyeran, et al.
Publicado: (2016)

Ras Oncogene-Mediated Progressive Silencing of Extracellular Superoxide Dismutase in Tumorigenesis
por: Cammarota, Francesca, et al.
Publicado: (2015)

ATOH8 binds SMAD3 to induce cellular senescence and prevent Ras-driven malignant transformation
por: Liu, Ximeng, et al.
Publicado: (2023)

Targeting the PI3K/Akt pathway in murine MDS/MPN driven by hyperactive Ras
por: Akutagawa, Jon, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_f0qs7g4itlfq7o1k553d8pniq6