Targeting few to help hundreds: JAK, MAPK and ROCK pathways as druggable targets in atypical chronic myeloid leukemia

Atypical Chronic Myeloid Leukemia (aCML) is a myeloproliferative neoplasm characterized by neutrophilic leukocytosis and dysgranulopoiesis. From a genetic point of view, aCML shows a heterogeneous mutational landscape with mutations affecting signal transduction proteins but also broad genetic modif...

Descripción completa

Detalles Bibliográficos
Autores principales: Rocca, Stefania, Carrà, Giovanna, Poggio, Pietro, Morotti, Alessandro, Brancaccio, Mara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817721/
https://www.ncbi.nlm.nih.gov/pubmed/29455651
http://dx.doi.org/10.1186/s12943-018-0774-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817721/
https://www.ncbi.nlm.nih.gov/pubmed/29455651
http://dx.doi.org/10.1186/s12943-018-0774-4

Ejemplares similares