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miR-19b enhances proliferation and apoptosis resistance via the EGFR signaling pathway by targeting PP2A and BIM in non-small cell lung cancer

BACKGROUND: Epidermal growth factor receptor (EGFR) mutations enable constitutive active downstream signaling of PI3K/AKT, KRAS/ERK and JAK/STAT pathways, and promote tumor progression by inducing uncontrolled proliferation, evasion of apoptosis and migration of non-small cell lung cancer (NSCLC). I...

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Detalles Bibliográficos
Autores principales:	Baumgartner, Ulrich, Berger, Fabienne, Hashemi Gheinani, Ali, Burgener, Sabrina Sofia, Monastyrskaya, Katia, Vassella, Erik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817797/ https://www.ncbi.nlm.nih.gov/pubmed/29455644 http://dx.doi.org/10.1186/s12943-018-0781-5

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