Function of the c-Met receptor tyrosine kinase in carcinogenesis and associated therapeutic opportunities

c-Met is a receptor tyrosine kinase belonging to the MET (MNNG HOS transforming gene) family, and is expressed on the surfaces of various cells. Hepatocyte growth factor (HGF) is the ligand for this receptor. The binding of HGF to c-Met initiates a series of intracellular signals that mediate embryo...

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Detalles Bibliográficos
Autores principales: Zhang, Yazhuo, Xia, Mengfang, Jin, Ke, Wang, Shufei, Wei, Hang, Fan, Chunmei, Wu, Yingfen, Li, Xiaoling, Li, Xiayu, Li, Guiyuan, Zeng, Zhaoyang, Xiong, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817860/
https://www.ncbi.nlm.nih.gov/pubmed/29455668
http://dx.doi.org/10.1186/s12943-018-0796-y

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