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Seroprevalence of hepatitis B virus in Taiwan 30 years after the commencement of the national vaccination program
BACKGROUND: In this study, the long-term efficacy of hepatitis B virus (HBV) vaccination was assessed using seroprevalence and an age–period–cohort (APC) model of HBV seromarkers among university entrants 30 years after the introduction of the national neonatal HBV vaccination program in Taiwan. MET...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PeerJ Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817935/ https://www.ncbi.nlm.nih.gov/pubmed/29472994 http://dx.doi.org/10.7717/peerj.4297 |
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author | Hu, Yang-Cheng Yeh, Chih-Ching Chen, Ruey-Yu Su, Chien-Tien Wang, Wen-Chang Bai, Chyi-Huey Chan, Chi-Fei Su, Fu Hsiung |
author_facet | Hu, Yang-Cheng Yeh, Chih-Ching Chen, Ruey-Yu Su, Chien-Tien Wang, Wen-Chang Bai, Chyi-Huey Chan, Chi-Fei Su, Fu Hsiung |
author_sort | Hu, Yang-Cheng |
collection | PubMed |
description | BACKGROUND: In this study, the long-term efficacy of hepatitis B virus (HBV) vaccination was assessed using seroprevalence and an age–period–cohort (APC) model of HBV seromarkers among university entrants 30 years after the introduction of the national neonatal HBV vaccination program in Taiwan. METHODS: In total, data of 17,611 university entrants who underwent university entrance health examinations between 2005 and 2016 were included. The seroprevalence of the HBV surface antigen (HBsAg) and the levels of the antibody against the HBV surface antigen (anti-HBs) in each year group and sex were calculated. The levels of the antibody against the HBV core antigen were examined only for 2012 and 2016. The APC model was used to analyze the HBV carrier rates. RESULTS: The chronic HBV infection (HBsAg positivity) rate decreased from 9.7% in university students born before June 1974 to <1.0% in students born after 1992. The prevalence of anti-HBs positivity declined, particularly between the 1984–1988 cohort (78.2%–53.2%) and the 1990–1994 cohort (60.6%–44.4%). Our APC model revealed that the chronic HBV carrier rate among the student population was affected significantly by age, period, and cohort (P < 0.001). CONCLUSIONS: HBV vaccination is one of the most effective strategies for preventing HBV infection. However, for complete eradication of HBV infection, the development of strategies that detect vaccination failure more effectively than current strategies do and early implementation of appropriate treatments are both necessary. |
format | Online Article Text |
id | pubmed-5817935 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | PeerJ Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-58179352018-02-22 Seroprevalence of hepatitis B virus in Taiwan 30 years after the commencement of the national vaccination program Hu, Yang-Cheng Yeh, Chih-Ching Chen, Ruey-Yu Su, Chien-Tien Wang, Wen-Chang Bai, Chyi-Huey Chan, Chi-Fei Su, Fu Hsiung PeerJ Epidemiology BACKGROUND: In this study, the long-term efficacy of hepatitis B virus (HBV) vaccination was assessed using seroprevalence and an age–period–cohort (APC) model of HBV seromarkers among university entrants 30 years after the introduction of the national neonatal HBV vaccination program in Taiwan. METHODS: In total, data of 17,611 university entrants who underwent university entrance health examinations between 2005 and 2016 were included. The seroprevalence of the HBV surface antigen (HBsAg) and the levels of the antibody against the HBV surface antigen (anti-HBs) in each year group and sex were calculated. The levels of the antibody against the HBV core antigen were examined only for 2012 and 2016. The APC model was used to analyze the HBV carrier rates. RESULTS: The chronic HBV infection (HBsAg positivity) rate decreased from 9.7% in university students born before June 1974 to <1.0% in students born after 1992. The prevalence of anti-HBs positivity declined, particularly between the 1984–1988 cohort (78.2%–53.2%) and the 1990–1994 cohort (60.6%–44.4%). Our APC model revealed that the chronic HBV carrier rate among the student population was affected significantly by age, period, and cohort (P < 0.001). CONCLUSIONS: HBV vaccination is one of the most effective strategies for preventing HBV infection. However, for complete eradication of HBV infection, the development of strategies that detect vaccination failure more effectively than current strategies do and early implementation of appropriate treatments are both necessary. PeerJ Inc. 2018-02-16 /pmc/articles/PMC5817935/ /pubmed/29472994 http://dx.doi.org/10.7717/peerj.4297 Text en ©2018 Hu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. |
spellingShingle | Epidemiology Hu, Yang-Cheng Yeh, Chih-Ching Chen, Ruey-Yu Su, Chien-Tien Wang, Wen-Chang Bai, Chyi-Huey Chan, Chi-Fei Su, Fu Hsiung Seroprevalence of hepatitis B virus in Taiwan 30 years after the commencement of the national vaccination program |
title | Seroprevalence of hepatitis B virus in Taiwan 30 years after the commencement of the national vaccination program |
title_full | Seroprevalence of hepatitis B virus in Taiwan 30 years after the commencement of the national vaccination program |
title_fullStr | Seroprevalence of hepatitis B virus in Taiwan 30 years after the commencement of the national vaccination program |
title_full_unstemmed | Seroprevalence of hepatitis B virus in Taiwan 30 years after the commencement of the national vaccination program |
title_short | Seroprevalence of hepatitis B virus in Taiwan 30 years after the commencement of the national vaccination program |
title_sort | seroprevalence of hepatitis b virus in taiwan 30 years after the commencement of the national vaccination program |
topic | Epidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817935/ https://www.ncbi.nlm.nih.gov/pubmed/29472994 http://dx.doi.org/10.7717/peerj.4297 |
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