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Cancer treatment in childhood and testicular function: the importance of the somatic environment
Testicular function and future fertility may be affected by cancer treatment during childhood. Whilst survival of the germ (stem) cells is critical for ensuring the potential for fertility in these patients, the somatic cell populations also play a crucial role in providing a suitable environment to...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bioscientifica Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817964/ https://www.ncbi.nlm.nih.gov/pubmed/29351905 http://dx.doi.org/10.1530/EC-17-0382 |
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author | Stukenborg, Jan-Bernd Jahnukainen, Kirsi Hutka, Marsida Mitchell, Rod T |
author_facet | Stukenborg, Jan-Bernd Jahnukainen, Kirsi Hutka, Marsida Mitchell, Rod T |
author_sort | Stukenborg, Jan-Bernd |
collection | PubMed |
description | Testicular function and future fertility may be affected by cancer treatment during childhood. Whilst survival of the germ (stem) cells is critical for ensuring the potential for fertility in these patients, the somatic cell populations also play a crucial role in providing a suitable environment to support germ cell maintenance and subsequent development. Regulation of the spermatogonial germ-stem cell niche involves many signalling pathways with hormonal influence from the hypothalamo-pituitary-gonadal axis. In this review, we describe the somatic cell populations that comprise the testicular germ-stem cell niche in humans and how they may be affected by cancer treatment during childhood. We also discuss the experimental models that may be utilized to manipulate the somatic environment and report the results of studies that investigate the potential role of somatic cells in the protection of the germ cells in the testis from cancer treatment. |
format | Online Article Text |
id | pubmed-5817964 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Bioscientifica Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-58179642018-02-23 Cancer treatment in childhood and testicular function: the importance of the somatic environment Stukenborg, Jan-Bernd Jahnukainen, Kirsi Hutka, Marsida Mitchell, Rod T Endocr Connect Review Testicular function and future fertility may be affected by cancer treatment during childhood. Whilst survival of the germ (stem) cells is critical for ensuring the potential for fertility in these patients, the somatic cell populations also play a crucial role in providing a suitable environment to support germ cell maintenance and subsequent development. Regulation of the spermatogonial germ-stem cell niche involves many signalling pathways with hormonal influence from the hypothalamo-pituitary-gonadal axis. In this review, we describe the somatic cell populations that comprise the testicular germ-stem cell niche in humans and how they may be affected by cancer treatment during childhood. We also discuss the experimental models that may be utilized to manipulate the somatic environment and report the results of studies that investigate the potential role of somatic cells in the protection of the germ cells in the testis from cancer treatment. Bioscientifica Ltd 2018-01-19 /pmc/articles/PMC5817964/ /pubmed/29351905 http://dx.doi.org/10.1530/EC-17-0382 Text en © 2018 The authors http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Stukenborg, Jan-Bernd Jahnukainen, Kirsi Hutka, Marsida Mitchell, Rod T Cancer treatment in childhood and testicular function: the importance of the somatic environment |
title | Cancer treatment in childhood and testicular function: the importance of the somatic environment |
title_full | Cancer treatment in childhood and testicular function: the importance of the somatic environment |
title_fullStr | Cancer treatment in childhood and testicular function: the importance of the somatic environment |
title_full_unstemmed | Cancer treatment in childhood and testicular function: the importance of the somatic environment |
title_short | Cancer treatment in childhood and testicular function: the importance of the somatic environment |
title_sort | cancer treatment in childhood and testicular function: the importance of the somatic environment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817964/ https://www.ncbi.nlm.nih.gov/pubmed/29351905 http://dx.doi.org/10.1530/EC-17-0382 |
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