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Cancer treatment in childhood and testicular function: the importance of the somatic environment

Testicular function and future fertility may be affected by cancer treatment during childhood. Whilst survival of the germ (stem) cells is critical for ensuring the potential for fertility in these patients, the somatic cell populations also play a crucial role in providing a suitable environment to...

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Autores principales: Stukenborg, Jan-Bernd, Jahnukainen, Kirsi, Hutka, Marsida, Mitchell, Rod T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817964/
https://www.ncbi.nlm.nih.gov/pubmed/29351905
http://dx.doi.org/10.1530/EC-17-0382
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author Stukenborg, Jan-Bernd
Jahnukainen, Kirsi
Hutka, Marsida
Mitchell, Rod T
author_facet Stukenborg, Jan-Bernd
Jahnukainen, Kirsi
Hutka, Marsida
Mitchell, Rod T
author_sort Stukenborg, Jan-Bernd
collection PubMed
description Testicular function and future fertility may be affected by cancer treatment during childhood. Whilst survival of the germ (stem) cells is critical for ensuring the potential for fertility in these patients, the somatic cell populations also play a crucial role in providing a suitable environment to support germ cell maintenance and subsequent development. Regulation of the spermatogonial germ-stem cell niche involves many signalling pathways with hormonal influence from the hypothalamo-pituitary-gonadal axis. In this review, we describe the somatic cell populations that comprise the testicular germ-stem cell niche in humans and how they may be affected by cancer treatment during childhood. We also discuss the experimental models that may be utilized to manipulate the somatic environment and report the results of studies that investigate the potential role of somatic cells in the protection of the germ cells in the testis from cancer treatment.
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spelling pubmed-58179642018-02-23 Cancer treatment in childhood and testicular function: the importance of the somatic environment Stukenborg, Jan-Bernd Jahnukainen, Kirsi Hutka, Marsida Mitchell, Rod T Endocr Connect Review Testicular function and future fertility may be affected by cancer treatment during childhood. Whilst survival of the germ (stem) cells is critical for ensuring the potential for fertility in these patients, the somatic cell populations also play a crucial role in providing a suitable environment to support germ cell maintenance and subsequent development. Regulation of the spermatogonial germ-stem cell niche involves many signalling pathways with hormonal influence from the hypothalamo-pituitary-gonadal axis. In this review, we describe the somatic cell populations that comprise the testicular germ-stem cell niche in humans and how they may be affected by cancer treatment during childhood. We also discuss the experimental models that may be utilized to manipulate the somatic environment and report the results of studies that investigate the potential role of somatic cells in the protection of the germ cells in the testis from cancer treatment. Bioscientifica Ltd 2018-01-19 /pmc/articles/PMC5817964/ /pubmed/29351905 http://dx.doi.org/10.1530/EC-17-0382 Text en © 2018 The authors http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Stukenborg, Jan-Bernd
Jahnukainen, Kirsi
Hutka, Marsida
Mitchell, Rod T
Cancer treatment in childhood and testicular function: the importance of the somatic environment
title Cancer treatment in childhood and testicular function: the importance of the somatic environment
title_full Cancer treatment in childhood and testicular function: the importance of the somatic environment
title_fullStr Cancer treatment in childhood and testicular function: the importance of the somatic environment
title_full_unstemmed Cancer treatment in childhood and testicular function: the importance of the somatic environment
title_short Cancer treatment in childhood and testicular function: the importance of the somatic environment
title_sort cancer treatment in childhood and testicular function: the importance of the somatic environment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5817964/
https://www.ncbi.nlm.nih.gov/pubmed/29351905
http://dx.doi.org/10.1530/EC-17-0382
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