mTORC1 signaling in hepatic lipid metabolism

The mechanistic target of rapamycin (mTOR) signaling pathway regulates many metabolic and physiological processes in different organs or tissues. Dysregulation of mTOR signaling has been implicated in many human diseases including obesity, diabetes, cancer, fatty liver diseases, and neuronal disorde...

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Detalles Bibliográficos
Autores principales: Han, Jinbo, Wang, Yiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818363/
https://www.ncbi.nlm.nih.gov/pubmed/28434145
http://dx.doi.org/10.1007/s13238-017-0409-3
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author Han, Jinbo
Wang, Yiguo
author_facet Han, Jinbo
Wang, Yiguo
author_sort Han, Jinbo
collection PubMed
description The mechanistic target of rapamycin (mTOR) signaling pathway regulates many metabolic and physiological processes in different organs or tissues. Dysregulation of mTOR signaling has been implicated in many human diseases including obesity, diabetes, cancer, fatty liver diseases, and neuronal disorders. Here we review recent progress in understanding how mTORC1 (mTOR complex 1) signaling regulates lipid metabolism in the liver.
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spelling pubmed-58183632018-02-26 mTORC1 signaling in hepatic lipid metabolism Han, Jinbo Wang, Yiguo Protein Cell Review The mechanistic target of rapamycin (mTOR) signaling pathway regulates many metabolic and physiological processes in different organs or tissues. Dysregulation of mTOR signaling has been implicated in many human diseases including obesity, diabetes, cancer, fatty liver diseases, and neuronal disorders. Here we review recent progress in understanding how mTORC1 (mTOR complex 1) signaling regulates lipid metabolism in the liver. Higher Education Press 2017-04-22 2018-02 /pmc/articles/PMC5818363/ /pubmed/28434145 http://dx.doi.org/10.1007/s13238-017-0409-3 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Han, Jinbo
Wang, Yiguo
mTORC1 signaling in hepatic lipid metabolism
title mTORC1 signaling in hepatic lipid metabolism
title_full mTORC1 signaling in hepatic lipid metabolism
title_fullStr mTORC1 signaling in hepatic lipid metabolism
title_full_unstemmed mTORC1 signaling in hepatic lipid metabolism
title_short mTORC1 signaling in hepatic lipid metabolism
title_sort mtorc1 signaling in hepatic lipid metabolism
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818363/
https://www.ncbi.nlm.nih.gov/pubmed/28434145
http://dx.doi.org/10.1007/s13238-017-0409-3
work_keys_str_mv AT hanjinbo mtorc1signalinginhepaticlipidmetabolism
AT wangyiguo mtorc1signalinginhepaticlipidmetabolism

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