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Heat: A Highly Efficient Skin Enhancer for Transdermal Drug Delivery

Advances in materials science and bionanotechnology have allowed the refinements of current drug delivery systems, expected to facilitate the development of personalized medicine. While dermatological topical pharmaceutical formulations such as foams, creams, lotions, gels, etc., have been proposed...

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Detalles Bibliográficos
Autores principales: Szunerits, Sabine, Boukherroub, Rabah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818408/
https://www.ncbi.nlm.nih.gov/pubmed/29497609
http://dx.doi.org/10.3389/fbioe.2018.00015
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author Szunerits, Sabine
Boukherroub, Rabah
author_facet Szunerits, Sabine
Boukherroub, Rabah
author_sort Szunerits, Sabine
collection PubMed
description Advances in materials science and bionanotechnology have allowed the refinements of current drug delivery systems, expected to facilitate the development of personalized medicine. While dermatological topical pharmaceutical formulations such as foams, creams, lotions, gels, etc., have been proposed for decades, these systems target mainly skin-based diseases. To treat systemic medical conditions as well as localized problems such as joint or muscle concerns, transdermal delivery systems (TDDSs), which use the skin as the main route of drug delivery, are very appealing. Over the years, these systems have shown to offer important advantages over oral as well as intravenous drug delivery routes. Besides being non-invasive and painless, TDDSs are able to deliver drugs with a short-half-life time more easily and are well adapted to eliminate frequent administrations to maintain constant drug delivery. The possibility of self-administration of a predetermined drug dose at defined time intervals makes it also the most convenient personalized point-of-care approach. The transdermal market still remains limited to a narrow range of drugs. While small and lipophilic drugs have been successfully delivered using TDDSs, this approach fails to deliver therapeutic macromolecules due to size-limited transport across the stratum corneum, the outermost layer of the epidermis. The low permeability of the stratum corneum to water-soluble drugs as well as macromolecules poses important challenges to transdermal administration. To widen the scope of drugs for transdermal delivery, new procedures to enhance skin permeation to hydrophilic drugs and macromolecules are under development. Next to iontophoresis and microneedle-based concepts, thermal-based approaches have shown great promise to enhance transdermal drug delivery of different therapeutics. In this inaugural article for the section “Frontiers in Bioengineering and Biotechnology,” the advances in this field and the handful of examples of thermal technologies for local and systemic transdermal drug delivery will be discussed and put into perspective.
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spelling pubmed-58184082018-03-01 Heat: A Highly Efficient Skin Enhancer for Transdermal Drug Delivery Szunerits, Sabine Boukherroub, Rabah Front Bioeng Biotechnol Bioengineering and Biotechnology Advances in materials science and bionanotechnology have allowed the refinements of current drug delivery systems, expected to facilitate the development of personalized medicine. While dermatological topical pharmaceutical formulations such as foams, creams, lotions, gels, etc., have been proposed for decades, these systems target mainly skin-based diseases. To treat systemic medical conditions as well as localized problems such as joint or muscle concerns, transdermal delivery systems (TDDSs), which use the skin as the main route of drug delivery, are very appealing. Over the years, these systems have shown to offer important advantages over oral as well as intravenous drug delivery routes. Besides being non-invasive and painless, TDDSs are able to deliver drugs with a short-half-life time more easily and are well adapted to eliminate frequent administrations to maintain constant drug delivery. The possibility of self-administration of a predetermined drug dose at defined time intervals makes it also the most convenient personalized point-of-care approach. The transdermal market still remains limited to a narrow range of drugs. While small and lipophilic drugs have been successfully delivered using TDDSs, this approach fails to deliver therapeutic macromolecules due to size-limited transport across the stratum corneum, the outermost layer of the epidermis. The low permeability of the stratum corneum to water-soluble drugs as well as macromolecules poses important challenges to transdermal administration. To widen the scope of drugs for transdermal delivery, new procedures to enhance skin permeation to hydrophilic drugs and macromolecules are under development. Next to iontophoresis and microneedle-based concepts, thermal-based approaches have shown great promise to enhance transdermal drug delivery of different therapeutics. In this inaugural article for the section “Frontiers in Bioengineering and Biotechnology,” the advances in this field and the handful of examples of thermal technologies for local and systemic transdermal drug delivery will be discussed and put into perspective. Frontiers Media S.A. 2018-02-15 /pmc/articles/PMC5818408/ /pubmed/29497609 http://dx.doi.org/10.3389/fbioe.2018.00015 Text en Copyright © 2018 Szunerits and Boukherroub. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Szunerits, Sabine
Boukherroub, Rabah
Heat: A Highly Efficient Skin Enhancer for Transdermal Drug Delivery
title Heat: A Highly Efficient Skin Enhancer for Transdermal Drug Delivery
title_full Heat: A Highly Efficient Skin Enhancer for Transdermal Drug Delivery
title_fullStr Heat: A Highly Efficient Skin Enhancer for Transdermal Drug Delivery
title_full_unstemmed Heat: A Highly Efficient Skin Enhancer for Transdermal Drug Delivery
title_short Heat: A Highly Efficient Skin Enhancer for Transdermal Drug Delivery
title_sort heat: a highly efficient skin enhancer for transdermal drug delivery
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818408/
https://www.ncbi.nlm.nih.gov/pubmed/29497609
http://dx.doi.org/10.3389/fbioe.2018.00015
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