Vulnerable Parkin Loss-of-Function Drosophila Dopaminergic Neurons Have Advanced Mitochondrial Aging, Mitochondrial Network Loss and Transiently Reduced Autophagosome Recruitment

Selective degeneration of substantia nigra dopaminergic (DA) neurons is a hallmark pathology of familial Parkinson’s disease (PD). While the mechanism of degeneration is elusive, abnormalities in mitochondrial function and turnover are strongly implicated. An Autosomal Recessive-Juvenile Parkinsonis...

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Detalles Bibliográficos
Autores principales: Cackovic, Juliana, Gutierrez-Luke, Susana, Call, Gerald B., Juba, Amber, O’Brien, Stephanie, Jun, Charles H., Buhlman, Lori M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818410/
https://www.ncbi.nlm.nih.gov/pubmed/29497364
http://dx.doi.org/10.3389/fncel.2018.00039

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