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Filling the Gaps in the Kirromycin Biosynthesis: Deciphering the Role of Genes Involved in Ethylmalonyl-CoA Supply and Tailoring Reactions

Kirromycin is the main product of the soil-dwelling Streptomyces collinus Tü 365. The elucidation of the biosynthetic pathway revealed that the antibiotic is synthesised via a unique combination of trans-/cis-AT type I polyketide synthases and non-ribosomal peptide synthetases (PKS I/NRPS). This was...

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Detalles Bibliográficos
Autores principales:	Robertsen, Helene L., Musiol-Kroll, Ewa M., Ding, Ling, Laiple, Kristina J., Hofeditz, Torben, Wohlleben, Wolfgang, Lee, Sang Yup, Grond, Stephanie, Weber, Tilmann
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818483/ https://www.ncbi.nlm.nih.gov/pubmed/29459765 http://dx.doi.org/10.1038/s41598-018-21507-6

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