C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction

Alpha-synuclein is known to bind to small unilamellar vesicles (SUVs) via its N terminus, which forms an amphipathic alpha-helix upon membrane interaction. Here we show that calcium binds to the C terminus of alpha-synuclein, therewith increasing its lipid-binding capacity. Using CEST-NMR, we reveal...

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Detalles Bibliográficos
Autores principales: Lautenschläger, Janin, Stephens, Amberley D., Fusco, Giuliana, Ströhl, Florian, Curry, Nathan, Zacharopoulou, Maria, Michel, Claire H., Laine, Romain, Nespovitaya, Nadezhda, Fantham, Marcus, Pinotsi, Dorothea, Zago, Wagner, Fraser, Paul, Tandon, Anurag, St George-Hyslop, Peter, Rees, Eric, Phillips, Jonathan J., De Simone, Alfonso, Kaminski, Clemens F., Schierle, Gabriele S. Kaminski
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818535/
https://www.ncbi.nlm.nih.gov/pubmed/29459792
http://dx.doi.org/10.1038/s41467-018-03111-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818535/
https://www.ncbi.nlm.nih.gov/pubmed/29459792
http://dx.doi.org/10.1038/s41467-018-03111-4

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