A Review of New Findings in Adult T-cell Leukemia–Lymphoma: A Focus on Current and Emerging Treatment Strategies

Adult T-cell leukemia–lymphoma (ATL), a rare and aggressive T-cell malignancy caused by human T-cell lymphotropic virus type 1 (HTLV-1), is associated with a poor prognosis. Evidence-based standard treatment options are lacking and outcomes are generally unsatisfactory, particularly for patients wit...

Descripción completa

Detalles Bibliográficos
Autores principales: Hermine, Olivier, Ramos, Juan Carlos, Tobinai, Kensei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818559/
https://www.ncbi.nlm.nih.gov/pubmed/29411267
http://dx.doi.org/10.1007/s12325-018-0658-4
_version_ 1783301047679188992
author Hermine, Olivier
Ramos, Juan Carlos
Tobinai, Kensei
author_facet Hermine, Olivier
Ramos, Juan Carlos
Tobinai, Kensei
author_sort Hermine, Olivier
collection PubMed
description Adult T-cell leukemia–lymphoma (ATL), a rare and aggressive T-cell malignancy caused by human T-cell lymphotropic virus type 1 (HTLV-1), is associated with a poor prognosis. Evidence-based standard treatment options are lacking and outcomes are generally unsatisfactory, particularly for patients with relapsed or refractory disease. Continued research is contributing to changing treatment landscape as a number of existing and investigational agents are evaluated. We describe the epidemiology of HTLV-1 and ATL, discuss the biology behind the disease, review current treatment practices and guidelines, and provide an overview of emerging therapies in ATL, with a focus on those for relapsed or refractory disease.
format Online
Article
Text
id pubmed-5818559
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Springer Healthcare
record_format MEDLINE/PubMed
spelling pubmed-58185592018-02-27 A Review of New Findings in Adult T-cell Leukemia–Lymphoma: A Focus on Current and Emerging Treatment Strategies Hermine, Olivier Ramos, Juan Carlos Tobinai, Kensei Adv Ther Review Adult T-cell leukemia–lymphoma (ATL), a rare and aggressive T-cell malignancy caused by human T-cell lymphotropic virus type 1 (HTLV-1), is associated with a poor prognosis. Evidence-based standard treatment options are lacking and outcomes are generally unsatisfactory, particularly for patients with relapsed or refractory disease. Continued research is contributing to changing treatment landscape as a number of existing and investigational agents are evaluated. We describe the epidemiology of HTLV-1 and ATL, discuss the biology behind the disease, review current treatment practices and guidelines, and provide an overview of emerging therapies in ATL, with a focus on those for relapsed or refractory disease. Springer Healthcare 2018-02-06 2018 /pmc/articles/PMC5818559/ /pubmed/29411267 http://dx.doi.org/10.1007/s12325-018-0658-4 Text en © The Author(s) 2018 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Hermine, Olivier
Ramos, Juan Carlos
Tobinai, Kensei
A Review of New Findings in Adult T-cell Leukemia–Lymphoma: A Focus on Current and Emerging Treatment Strategies
title A Review of New Findings in Adult T-cell Leukemia–Lymphoma: A Focus on Current and Emerging Treatment Strategies
title_full A Review of New Findings in Adult T-cell Leukemia–Lymphoma: A Focus on Current and Emerging Treatment Strategies
title_fullStr A Review of New Findings in Adult T-cell Leukemia–Lymphoma: A Focus on Current and Emerging Treatment Strategies
title_full_unstemmed A Review of New Findings in Adult T-cell Leukemia–Lymphoma: A Focus on Current and Emerging Treatment Strategies
title_short A Review of New Findings in Adult T-cell Leukemia–Lymphoma: A Focus on Current and Emerging Treatment Strategies
title_sort review of new findings in adult t-cell leukemia–lymphoma: a focus on current and emerging treatment strategies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818559/
https://www.ncbi.nlm.nih.gov/pubmed/29411267
http://dx.doi.org/10.1007/s12325-018-0658-4
work_keys_str_mv AT hermineolivier areviewofnewfindingsinadulttcellleukemialymphomaafocusoncurrentandemergingtreatmentstrategies
AT ramosjuancarlos areviewofnewfindingsinadulttcellleukemialymphomaafocusoncurrentandemergingtreatmentstrategies
AT tobinaikensei areviewofnewfindingsinadulttcellleukemialymphomaafocusoncurrentandemergingtreatmentstrategies
AT hermineolivier reviewofnewfindingsinadulttcellleukemialymphomaafocusoncurrentandemergingtreatmentstrategies
AT ramosjuancarlos reviewofnewfindingsinadulttcellleukemialymphomaafocusoncurrentandemergingtreatmentstrategies
AT tobinaikensei reviewofnewfindingsinadulttcellleukemialymphomaafocusoncurrentandemergingtreatmentstrategies

Ejemplares similares