Cargando…

The impact of GI events on persistence and adherence to osteoporosis treatment: 3-, 6-, and 12-month findings in the MUSIC-OS study

SUMMARY: The goal of this multinational, prospective, observational study was to examine the relationship between gastrointestinal (GI) events and self-reported levels of medication adherence and persistence in postmenopausal women. A total of 73.9% of patients remained on their osteoporosis (OP) th...

Descripción completa

Detalles Bibliográficos
Autores principales: Modi, A., Sen, S., Adachi, J. D., Adami, S., Cortet, B., Cooper, A. L., Geusens, P., Mellström, D., Weaver, J. P., van den Bergh, J. P., Keown, P., Sajjan, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer London 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818582/
https://www.ncbi.nlm.nih.gov/pubmed/29110061
http://dx.doi.org/10.1007/s00198-017-4271-1
_version_ 1783301053184212992
author Modi, A.
Sen, S.
Adachi, J. D.
Adami, S.
Cortet, B.
Cooper, A. L.
Geusens, P.
Mellström, D.
Weaver, J. P.
van den Bergh, J. P.
Keown, P.
Sajjan, S.
author_facet Modi, A.
Sen, S.
Adachi, J. D.
Adami, S.
Cortet, B.
Cooper, A. L.
Geusens, P.
Mellström, D.
Weaver, J. P.
van den Bergh, J. P.
Keown, P.
Sajjan, S.
author_sort Modi, A.
collection PubMed
description SUMMARY: The goal of this multinational, prospective, observational study was to examine the relationship between gastrointestinal (GI) events and self-reported levels of medication adherence and persistence in postmenopausal women. A total of 73.9% of patients remained on their osteoporosis (OP) therapy at month 12, although the presence of a GI event at baseline, month 3, and month 6 significantly reduced month 12 persistence among new users. The odds of a month-12 ADEOS score ≥ 20 were significantly lower among patients who experienced a GI event between baseline and month 6. The occurrence of GI events was observed to be associated with a lower likelihood of patient adherence and persistence to OP medication. INTRODUCTION: This study examines the relationship between gastrointestinal (GI) events and self-reported adherence and persistence with initial osteoporosis (OP) therapy over the course of the first 12 months of treatment. METHODS: The Medication Use Patterns, Treatment Satisfaction, and Inadequate Control of Osteoporosis Study was a multinational, prospective, observational study examining the impact of GI events on OP management in postmenopausal women. Information regarding GI events was collected at the time of enrollment and at months 3, 6, and 12 of follow-up. Patients reported GI events and medication persistence and completed the 12-item Adherence Evaluation of Osteoporosis treatment (ADEOS) questionnaire. Multivariate logistic and general linear models examined the association between GI events at various time points and persistence and adherence at month 12. RESULTS: The study enrolled 2943 women; 22.8% were classified as new users of OP therapy and the remainder were considered experienced users. Across all patients, 68.1% reported GI events at baseline; by month 12, over 80% of subjects who completed follow-up reported at least one GI problem. The majority of patients (86.7%) were treated only with bisphosphonates at baseline. At month 12, 73.9% of patients remained on therapy; logistic regression revealed that those with GI problems by month 6 were significantly less likely to persist with treatment, after adjusting for other factors. The odds of a month 12 ADEOS score ≥ 20 (considered predictive of adherence) were significantly lower among patients who experienced a GI event between baseline and month 6. CONCLUSIONS: The occurrence of GI events was associated with a lower likelihood of patient adherence to and persistence with OP medication.
format Online
Article
Text
id pubmed-5818582
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Springer London
record_format MEDLINE/PubMed
spelling pubmed-58185822018-02-27 The impact of GI events on persistence and adherence to osteoporosis treatment: 3-, 6-, and 12-month findings in the MUSIC-OS study Modi, A. Sen, S. Adachi, J. D. Adami, S. Cortet, B. Cooper, A. L. Geusens, P. Mellström, D. Weaver, J. P. van den Bergh, J. P. Keown, P. Sajjan, S. Osteoporos Int Original Article SUMMARY: The goal of this multinational, prospective, observational study was to examine the relationship between gastrointestinal (GI) events and self-reported levels of medication adherence and persistence in postmenopausal women. A total of 73.9% of patients remained on their osteoporosis (OP) therapy at month 12, although the presence of a GI event at baseline, month 3, and month 6 significantly reduced month 12 persistence among new users. The odds of a month-12 ADEOS score ≥ 20 were significantly lower among patients who experienced a GI event between baseline and month 6. The occurrence of GI events was observed to be associated with a lower likelihood of patient adherence and persistence to OP medication. INTRODUCTION: This study examines the relationship between gastrointestinal (GI) events and self-reported adherence and persistence with initial osteoporosis (OP) therapy over the course of the first 12 months of treatment. METHODS: The Medication Use Patterns, Treatment Satisfaction, and Inadequate Control of Osteoporosis Study was a multinational, prospective, observational study examining the impact of GI events on OP management in postmenopausal women. Information regarding GI events was collected at the time of enrollment and at months 3, 6, and 12 of follow-up. Patients reported GI events and medication persistence and completed the 12-item Adherence Evaluation of Osteoporosis treatment (ADEOS) questionnaire. Multivariate logistic and general linear models examined the association between GI events at various time points and persistence and adherence at month 12. RESULTS: The study enrolled 2943 women; 22.8% were classified as new users of OP therapy and the remainder were considered experienced users. Across all patients, 68.1% reported GI events at baseline; by month 12, over 80% of subjects who completed follow-up reported at least one GI problem. The majority of patients (86.7%) were treated only with bisphosphonates at baseline. At month 12, 73.9% of patients remained on therapy; logistic regression revealed that those with GI problems by month 6 were significantly less likely to persist with treatment, after adjusting for other factors. The odds of a month 12 ADEOS score ≥ 20 (considered predictive of adherence) were significantly lower among patients who experienced a GI event between baseline and month 6. CONCLUSIONS: The occurrence of GI events was associated with a lower likelihood of patient adherence to and persistence with OP medication. Springer London 2017-11-06 2018 /pmc/articles/PMC5818582/ /pubmed/29110061 http://dx.doi.org/10.1007/s00198-017-4271-1 Text en © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Modi, A.
Sen, S.
Adachi, J. D.
Adami, S.
Cortet, B.
Cooper, A. L.
Geusens, P.
Mellström, D.
Weaver, J. P.
van den Bergh, J. P.
Keown, P.
Sajjan, S.
The impact of GI events on persistence and adherence to osteoporosis treatment: 3-, 6-, and 12-month findings in the MUSIC-OS study
title The impact of GI events on persistence and adherence to osteoporosis treatment: 3-, 6-, and 12-month findings in the MUSIC-OS study
title_full The impact of GI events on persistence and adherence to osteoporosis treatment: 3-, 6-, and 12-month findings in the MUSIC-OS study
title_fullStr The impact of GI events on persistence and adherence to osteoporosis treatment: 3-, 6-, and 12-month findings in the MUSIC-OS study
title_full_unstemmed The impact of GI events on persistence and adherence to osteoporosis treatment: 3-, 6-, and 12-month findings in the MUSIC-OS study
title_short The impact of GI events on persistence and adherence to osteoporosis treatment: 3-, 6-, and 12-month findings in the MUSIC-OS study
title_sort impact of gi events on persistence and adherence to osteoporosis treatment: 3-, 6-, and 12-month findings in the music-os study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818582/
https://www.ncbi.nlm.nih.gov/pubmed/29110061
http://dx.doi.org/10.1007/s00198-017-4271-1
work_keys_str_mv AT modia theimpactofgieventsonpersistenceandadherencetoosteoporosistreatment36and12monthfindingsinthemusicosstudy
AT sens theimpactofgieventsonpersistenceandadherencetoosteoporosistreatment36and12monthfindingsinthemusicosstudy
AT adachijd theimpactofgieventsonpersistenceandadherencetoosteoporosistreatment36and12monthfindingsinthemusicosstudy
AT adamis theimpactofgieventsonpersistenceandadherencetoosteoporosistreatment36and12monthfindingsinthemusicosstudy
AT cortetb theimpactofgieventsonpersistenceandadherencetoosteoporosistreatment36and12monthfindingsinthemusicosstudy
AT cooperal theimpactofgieventsonpersistenceandadherencetoosteoporosistreatment36and12monthfindingsinthemusicosstudy
AT geusensp theimpactofgieventsonpersistenceandadherencetoosteoporosistreatment36and12monthfindingsinthemusicosstudy
AT mellstromd theimpactofgieventsonpersistenceandadherencetoosteoporosistreatment36and12monthfindingsinthemusicosstudy
AT weaverjp theimpactofgieventsonpersistenceandadherencetoosteoporosistreatment36and12monthfindingsinthemusicosstudy
AT vandenberghjp theimpactofgieventsonpersistenceandadherencetoosteoporosistreatment36and12monthfindingsinthemusicosstudy
AT keownp theimpactofgieventsonpersistenceandadherencetoosteoporosistreatment36and12monthfindingsinthemusicosstudy
AT sajjans theimpactofgieventsonpersistenceandadherencetoosteoporosistreatment36and12monthfindingsinthemusicosstudy
AT modia impactofgieventsonpersistenceandadherencetoosteoporosistreatment36and12monthfindingsinthemusicosstudy
AT sens impactofgieventsonpersistenceandadherencetoosteoporosistreatment36and12monthfindingsinthemusicosstudy
AT adachijd impactofgieventsonpersistenceandadherencetoosteoporosistreatment36and12monthfindingsinthemusicosstudy
AT adamis impactofgieventsonpersistenceandadherencetoosteoporosistreatment36and12monthfindingsinthemusicosstudy
AT cortetb impactofgieventsonpersistenceandadherencetoosteoporosistreatment36and12monthfindingsinthemusicosstudy
AT cooperal impactofgieventsonpersistenceandadherencetoosteoporosistreatment36and12monthfindingsinthemusicosstudy
AT geusensp impactofgieventsonpersistenceandadherencetoosteoporosistreatment36and12monthfindingsinthemusicosstudy
AT mellstromd impactofgieventsonpersistenceandadherencetoosteoporosistreatment36and12monthfindingsinthemusicosstudy
AT weaverjp impactofgieventsonpersistenceandadherencetoosteoporosistreatment36and12monthfindingsinthemusicosstudy
AT vandenberghjp impactofgieventsonpersistenceandadherencetoosteoporosistreatment36and12monthfindingsinthemusicosstudy
AT keownp impactofgieventsonpersistenceandadherencetoosteoporosistreatment36and12monthfindingsinthemusicosstudy
AT sajjans impactofgieventsonpersistenceandadherencetoosteoporosistreatment36and12monthfindingsinthemusicosstudy