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Prediction of liver toxicity and mode of action using metabolomics in vitro in HepG2 cells

Liver toxicity is a leading systemic toxicity of drugs and chemicals demanding more human-relevant, high throughput, cost effective in vitro solutions. In addition to contributing to animal welfare, in vitro techniques facilitate exploring and understanding the molecular mechanisms underlying toxici...

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Detalles Bibliográficos
Autores principales:	Ramirez, Tzutzuy, Strigun, Alexander, Verlohner, Andreas, Huener, Hans-Albrecht, Peter, Erik, Herold, Michael, Bordag, Natalie, Mellert, Werner, Walk, Tilmann, Spitzer, Michael, Jiang, Xiaoqi, Sperber, Saskia, Hofmann, Thomas, Hartung, Thomas, Kamp, Hennicke, van Ravenzwaay, Ben
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2017
Materias:	Organ Toxicity and Mechanisms
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818600/ https://www.ncbi.nlm.nih.gov/pubmed/28965233 http://dx.doi.org/10.1007/s00204-017-2079-6

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