Roles of cytosolic phospholipase A(2)α in reproductive and systemic toxicities in 2,3,7,8-tetrachlorodibenzo-p-dioxin-exposed mice

Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces a variety of toxicities upon binding of TCDD to aryl hydrocarbon receptor. Although this binding upregulates the synthesis of prostaglandins and their related lipid mediators via cytosolic phospholipase A(2)α (cPLA(2)α), toxicological si...

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Detalles Bibliográficos
Autores principales: Fujisawa, Nozomi, Yoshioka, Wataru, Yanagisawa, Hiroyuki, Tohyama, Chiharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Molecular Toxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818604/
https://www.ncbi.nlm.nih.gov/pubmed/29043426
http://dx.doi.org/10.1007/s00204-017-2081-z

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