Cargando…

Identification and characterization of sodium and chloride-dependent gamma-aminobutyric acid (GABA) transporters from eukaryotic pathogens as a potential drug target

We explored 285 completed eukaryotic pathogen genomes for GABA transporter proteins as effective chemotherapy targets. We identified 8 GABA proteins that spread across 4 phyla with 5 different pathogen species; Eimeria mitis Houghton, Neospora caninum Liverpool, S. mansoni, S. haematobium and Trichi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Otarigho, Benson, Falade, Mofolusho O
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Biomedical Informatics 2018
Materias:	Hypothesis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818639/ https://www.ncbi.nlm.nih.gov/pubmed/29497256 http://dx.doi.org/10.6026/97320630014021

Ejemplares similares

Analysis of antibiotics resistant genes in different strains of Staphylococcus aureus
por: Otarigho, Benson, et al.
Publicado: (2018)

Does gamma-aminobutyric acid (GABA) influence the development of chronic inflammation in rheumatoid arthritis?
por: Kelley, James M, et al.
Publicado: (2008)

Comparative Functional Study of Thioester-containing Related Proteins in the Recently Sequenced Genome of Biomphalaria glabrata
por: FALADE, Mofolusho O., et al.
Publicado: (2018)

Computational Screening of Approved Drugs for Inhibition of the Antibiotic Resistance Gene mecA in Methicillin-Resistant Staphylococcus aureus (MRSA) Strains
por: Otarigho, Benson, et al.
Publicado: (2023)

Natural Perylenequinone Compounds as Potent Inhibitors of Schistosoma mansoni Glutathione S-Transferase
por: Otarigho, Benson, et al.
Publicado: (2023)

Insights from the shotgun-based proteomics analysis of Biomphalaria glabrata
por: Otarigho, Benson, et al.
Publicado: (2021)

DNA barcoding of Clarias gariepinus, Coptodon zillii and Sarotherodon melanotheron from Southwestern Nigeria
por: Falade, Mofolusho O., et al.
Publicado: (2016)

Leaf Senescence and GABA Shunt
por: Ansari, Mohammad Israil, et al.
Publicado: (2014)

The GABA–Working Memory Relationship in Alzheimer’s Disease
por: Mandal, Pravat K., et al.
Publicado: (2017)

Capacitation of mouse sperm is modulated by gamma-aminobutyric acid (GABA) concentration
por: KURATA, Shouhei, et al.
Publicado: (2019)

Insights into binding events of GABA- and Tiagabine- analogues in the Gamma-Aminobutyric Acid Transporter 1 by means of Molecular Modelling
por: Zdrazil, Barbara, et al.
Publicado: (2012)

Origin of phagotrophic eukaryotes as social cheaters in microbial biofilms
por: Jékely, Gáspár
Publicado: (2007)

Uniting sex and eukaryote origins in an emerging oxygenic world
por: Gross, Jeferson, et al.
Publicado: (2010)

Investigation of Gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility
por: Fernandez, Francesca, et al.
Publicado: (2008)

United States Pharmacopeia (USP) Safety Review of Gamma-Aminobutyric Acid (GABA)
por: Oketch-Rabah, Hellen A., et al.
Publicado: (2021)

Accumulation and Transformation of Biogenic Amines and Gamma-Aminobutyric Acid (GABA) in Chickpea Sourdough
por: Polak, Tomaž, et al.
Publicado: (2021)

Gamma‐aminobutyric acid (GABA) can affect physiological processes in preimplantation embryos via GABA(A) and GABA(B) receptors
por: Kovaříková, Veronika, et al.
Publicado: (2023)

Mitochondrial DNA, chloroplast DNA and the origins of development in eukaryotic organisms
por: Bendich, Arnold J
Publicado: (2010)

Molecular docking based screening of GABA (A) receptor inhibitors from plant derivatives
por: Sahila, Mohammed Marunnan, et al.
Publicado: (2015)

Gamma-Aminobutyric Acid (GABA) Inhibits α-Melanocyte-Stimulating Hormone-Induced Melanogenesis through GABA(A) and GABA(B) Receptors
por: Molagoda, Ilandarage Menu Neelaka, et al.
Publicado: (2021)

Functional Characterization of the γ-Aminobutyric Acid Transporter from Mycobacterium smegmatis MC(2) 155 Reveals Sodium-Driven GABA Transport
por: Pavić, Ana, et al.
Publicado: (2021)

Oligomerization of the heteromeric γ-aminobutyric acid receptor GABA(B) in a eukaryotic cell-free system
por: Ullrich, Jessica, et al.
Publicado: (2022)

Comparative analysis of prokaryotic and eukaryotic transcription factors using machine-learning techniques
por: Nilkanta, Chowdhury, et al.
Publicado: (2018)

Desensitization of Gamma Aminobutyric Acid (GABA) Receptors in Muscle Fibers of the Crab Cancer borealis
por: Epstein, René, et al.
Publicado: (1970)

Computer aided identification of sodium channel blockers in the clinical treatment of epilepsy using molecular docking tools
por: Shaheen, Uzma, et al.
Publicado: (2015)

The use of deuterium-labeled gamma-aminobutyric (D(6)-GABA) to study uptake, translocation, and metabolism of exogenous GABA in plants
por: Hijaz, Faraj, et al.
Publicado: (2020)

Phylogenetic and Comparative Sequence Analysis of Thermostable Alpha Amylases of kingdom Archea, Prokaryotes and Eukaryotes
por: Huma, Tayyaba, et al.
Publicado: (2014)

Gamma-Aminobutyric Acid (GABA) Promotes Growth in Zebrafish Larvae by Inducing IGF-1 Expression via GABA(A) and GABA(B) Receptors
por: Athapaththu, Athapaththu Mudiyanselage Gihan Kavinda, et al.
Publicado: (2021)

Phylogenetic Analysis of the vesicular fusion SNARE machinery revealing its functional divergence across Eukaryotes
por: Khurana, Gagandeep K., et al.
Publicado: (2018)

Identification of glutamate ABC-Transporter component in Clostridium perfringens as a putative drug target
por: Bhatia, Bharti, et al.
Publicado: (2014)

Computational identification of putative miRNAs and their target genes in pathogenic amoeba Naegleria fowleri
por: Padmashree, Dyavegowda, et al.
Publicado: (2015)

Division of labour in a matrix, rather than phagocytosis or endosymbiosis, as a route for the origin of eukaryotic cells
por: Bateman, Andrew
Publicado: (2020)

Identification and characterization of the Fasciola hepatica sodium- and chloride-dependent taurine transporter
por: Hamali, Bulut, et al.
Publicado: (2018)

Neuronal gamma-aminobutyric acid (GABA) type A receptors undergo cognate ligand chaperoning in the endoplasmic reticulum by endogenous GABA
por: Wang, Ping, et al.
Publicado: (2015)

Identification of potential apicoplast associated therapeutic targets in human and animal pathogen Toxoplasma gondii ME49
por: Saremy, Sadegh, et al.
Publicado: (2011)

Identification of long non-coding RNA in rice lines resistant to Rice blast pathogen Maganaporthe oryzae
por: Jain, Priyanka, et al.
Publicado: (2017)

SVM based model generation for binding site prediction on helix turn helix motif type of transcription factors in eukaryotes
por: Mukherjee, Koel, et al.
Publicado: (2013)

A functional role for both γ-aminobutyric acid (GABA) transporter-1 and GABA transporter-3 in the modulation of extracellular GABA and GABAergic tonic conductances in the rat hippocampus
por: Kersanté, Flavie, et al.
Publicado: (2013)

A Fluorescence-Coupled Assay for Gamma Aminobutyric Acid (GABA) Reveals Metabolic Stress-Induced Modulation of GABA Content in Neuroendocrine Cancer
por: Ippolito, Joseph E., et al.
Publicado: (2014)

Gamma-aminobutyric acid (GABA) promotes recovery from spinal cord injury in lampreys: role of GABA receptors and perspective on the translation to mammals
por: Romaus-Sanjurjo, Daniel, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_rq60c1gmcm32f3tk2f56rvt2pg