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Liver Illness and Psoriatic Patients
Psoriasis is a chronic inflammatory disease of the skin affecting approximately 2% of the world's population. Systemic treatments, including methotrexate and cyclosporin, are associated with potential hepatotoxicity, due to either direct liver damage or immunosuppression or both immunomediated...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818942/ https://www.ncbi.nlm.nih.gov/pubmed/29546055 http://dx.doi.org/10.1155/2018/3140983 |
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author | Fiore, Marco Leone, Sebastiano Maraolo, Alberto Enrico Berti, Emilio Damiani, Giovanni |
author_facet | Fiore, Marco Leone, Sebastiano Maraolo, Alberto Enrico Berti, Emilio Damiani, Giovanni |
author_sort | Fiore, Marco |
collection | PubMed |
description | Psoriasis is a chronic inflammatory disease of the skin affecting approximately 2% of the world's population. Systemic treatments, including methotrexate and cyclosporin, are associated with potential hepatotoxicity, due to either direct liver damage or immunosuppression or both immunomediated and a direct liver injury; therefore, treatment of patients with psoriasis poses a therapeutic challenge. The aim of this minireview is to help clinicians in the management of psoriatic patients who develop signs of liver dysfunction. To find relevant articles, a comprehensive search was performed on PubMed, EMBASE, and Cochrane with appropriate combinations of the following keywords being considered: viral hepatitis, nonalcoholic fatty liver disease, psoriasis, hepatotoxicity, drug toxicity, cholestasis, and autoimmune liver diseases. |
format | Online Article Text |
id | pubmed-5818942 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-58189422018-03-15 Liver Illness and Psoriatic Patients Fiore, Marco Leone, Sebastiano Maraolo, Alberto Enrico Berti, Emilio Damiani, Giovanni Biomed Res Int Review Article Psoriasis is a chronic inflammatory disease of the skin affecting approximately 2% of the world's population. Systemic treatments, including methotrexate and cyclosporin, are associated with potential hepatotoxicity, due to either direct liver damage or immunosuppression or both immunomediated and a direct liver injury; therefore, treatment of patients with psoriasis poses a therapeutic challenge. The aim of this minireview is to help clinicians in the management of psoriatic patients who develop signs of liver dysfunction. To find relevant articles, a comprehensive search was performed on PubMed, EMBASE, and Cochrane with appropriate combinations of the following keywords being considered: viral hepatitis, nonalcoholic fatty liver disease, psoriasis, hepatotoxicity, drug toxicity, cholestasis, and autoimmune liver diseases. Hindawi 2018-02-06 /pmc/articles/PMC5818942/ /pubmed/29546055 http://dx.doi.org/10.1155/2018/3140983 Text en Copyright © 2018 Marco Fiore et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Fiore, Marco Leone, Sebastiano Maraolo, Alberto Enrico Berti, Emilio Damiani, Giovanni Liver Illness and Psoriatic Patients |
title | Liver Illness and Psoriatic Patients |
title_full | Liver Illness and Psoriatic Patients |
title_fullStr | Liver Illness and Psoriatic Patients |
title_full_unstemmed | Liver Illness and Psoriatic Patients |
title_short | Liver Illness and Psoriatic Patients |
title_sort | liver illness and psoriatic patients |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818942/ https://www.ncbi.nlm.nih.gov/pubmed/29546055 http://dx.doi.org/10.1155/2018/3140983 |
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