Combination of Mitochondrial and Plasma Membrane Citrate Transporter Inhibitors Inhibits De Novo Lipogenesis Pathway and Triggers Apoptosis in Hepatocellular Carcinoma Cells

Increased expression levels of both mitochondrial citrate transporter (CTP) and plasma membrane citrate transporter (PMCT) proteins have been found in various cancers. The transported citrates by these two transporter proteins provide acetyl-CoA precursors for the de novo lipogenesis (DNL) pathway t...

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Detalles Bibliográficos
Autores principales: Poolsri, Wan-angkan, Phokrai, Phornpun, Suwankulanan, Somrudee, Phakdeeto, Narinthorn, Phunsomboon, Pattamaphorn, Pekthong, Dumrongsak, Richert, Lysiane, Pongcharoen, Sutatip, Srisawang, Piyarat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818947/
https://www.ncbi.nlm.nih.gov/pubmed/29546056
http://dx.doi.org/10.1155/2018/3683026

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