A Severe Case of Ipilimumab-Induced Ileocolitis Refractory to Glucocorticosteroids and Infliximab

Ipilimumab is a monoclonal antibody that works as an immunotherapeutic agent through selective targeting of T cells to strengthen the response to metastatic melanoma. It is well known that this pharmaceutical agent can cause the adverse effect of colitis. We report a rare presentation of ileocolitis...

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Detalles Bibliográficos
Autores principales: Poushanchi, Behdod, Vallabh, Hiren, Reynolds, Gorman Joel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818971/
https://www.ncbi.nlm.nih.gov/pubmed/29552363
http://dx.doi.org/10.1155/2018/2431503
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author Poushanchi, Behdod
Vallabh, Hiren
Reynolds, Gorman Joel
author_facet Poushanchi, Behdod
Vallabh, Hiren
Reynolds, Gorman Joel
author_sort Poushanchi, Behdod
collection PubMed
description Ipilimumab is a monoclonal antibody that works as an immunotherapeutic agent through selective targeting of T cells to strengthen the response to metastatic melanoma. It is well known that this pharmaceutical agent can cause the adverse effect of colitis. We report a rare presentation of ileocolitis refractory to both glucocorticosteroids and infliximab with a resultant pneumatosis and perforation requiring subtotal colectomy and end ileostomy.
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spelling pubmed-58189712018-03-18 A Severe Case of Ipilimumab-Induced Ileocolitis Refractory to Glucocorticosteroids and Infliximab Poushanchi, Behdod Vallabh, Hiren Reynolds, Gorman Joel Case Rep Gastrointest Med Case Report Ipilimumab is a monoclonal antibody that works as an immunotherapeutic agent through selective targeting of T cells to strengthen the response to metastatic melanoma. It is well known that this pharmaceutical agent can cause the adverse effect of colitis. We report a rare presentation of ileocolitis refractory to both glucocorticosteroids and infliximab with a resultant pneumatosis and perforation requiring subtotal colectomy and end ileostomy. Hindawi 2018-02-06 /pmc/articles/PMC5818971/ /pubmed/29552363 http://dx.doi.org/10.1155/2018/2431503 Text en Copyright © 2018 Behdod Poushanchi et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Poushanchi, Behdod
Vallabh, Hiren
Reynolds, Gorman Joel
A Severe Case of Ipilimumab-Induced Ileocolitis Refractory to Glucocorticosteroids and Infliximab
title A Severe Case of Ipilimumab-Induced Ileocolitis Refractory to Glucocorticosteroids and Infliximab
title_full A Severe Case of Ipilimumab-Induced Ileocolitis Refractory to Glucocorticosteroids and Infliximab
title_fullStr A Severe Case of Ipilimumab-Induced Ileocolitis Refractory to Glucocorticosteroids and Infliximab
title_full_unstemmed A Severe Case of Ipilimumab-Induced Ileocolitis Refractory to Glucocorticosteroids and Infliximab
title_short A Severe Case of Ipilimumab-Induced Ileocolitis Refractory to Glucocorticosteroids and Infliximab
title_sort severe case of ipilimumab-induced ileocolitis refractory to glucocorticosteroids and infliximab
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818971/
https://www.ncbi.nlm.nih.gov/pubmed/29552363
http://dx.doi.org/10.1155/2018/2431503
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