Familial human prion diseases associated with prion protein mutations Y226X and G131V are transmissible to transgenic mice expressing human prion protein

Human familial prion diseases are associated with mutations at 34 different prion protein (PrP) amino acid residues. However, it is unclear whether infectious prions are found in all cases. Mutant PrP itself may be neurotoxic, or alternatively, PrP mutation might predispose to spontaneous formation...

Descripción completa

Detalles Bibliográficos
Autores principales: Race, Brent, Williams, Katie, Hughson, Andrew G., Jansen, Casper, Parchi, Piero, Rozemuller, Annemieke J. M., Chesebro, Bruce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819089/
https://www.ncbi.nlm.nih.gov/pubmed/29458424
http://dx.doi.org/10.1186/s40478-018-0516-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819089/
https://www.ncbi.nlm.nih.gov/pubmed/29458424
http://dx.doi.org/10.1186/s40478-018-0516-2

Ejemplares similares