A novel generation 1928zT2 CAR T cells induce remission in extramedullary relapse of acute lymphoblastic leukemia

BACKGROUND: Anti-CD19 chimeric antigen receptor (CAR) T cells have shown promise in the treatment of B cell acute lymphocytic leukemia (B-ALL). However, its efficacy in B-ALL patients with extramedullary involvement is limited due to poor responses and neurotoxicity. Here, we utilized a third genera...

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Detalles Bibliográficos
Autores principales: Weng, Jianyu, Lai, Peilong, Qin, Le, Lai, Yunxin, Jiang, Zhiwu, Luo, Chenwei, Huang, Xin, Wu, Suijing, Shao, Dan, Deng, Chengxin, Huang, Lisi, Lu, Zesheng, Zhou, Maohua, Zeng, Lingji, Chen, Dongmei, Wang, Yulian, Chen, Xiaomei, Geng, Suxia, Robert, Weinkove, Tang, Zhaoyang, He, Chang, Li, Peng, Du, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819207/
https://www.ncbi.nlm.nih.gov/pubmed/29458388
http://dx.doi.org/10.1186/s13045-018-0572-x

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