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Plasmacytoid Urothelial Carcinoma of Ureter with Retroperitoneal Metastasis: A Case Report

Patient: Male, 60 Final Diagnosis: Plasmacytoid urothelial carcinoma of ureter Symptoms: Constipation • epigastric pain • microscopic hematuria • nausea • vomiting Medication: — Clinical Procedure: — Specialty: Oncology OBJECTIVE: Rare disease BACKGROUND: Plasmacytoid is a rare histological variant...

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Detalles Bibliográficos
Autores principales: Jibril, Alexis, Stevens, Andrew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819306/
https://www.ncbi.nlm.nih.gov/pubmed/29434183
http://dx.doi.org/10.12659/AJCR.906679
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author Jibril, Alexis
Stevens, Andrew C.
author_facet Jibril, Alexis
Stevens, Andrew C.
author_sort Jibril, Alexis
collection PubMed
description Patient: Male, 60 Final Diagnosis: Plasmacytoid urothelial carcinoma of ureter Symptoms: Constipation • epigastric pain • microscopic hematuria • nausea • vomiting Medication: — Clinical Procedure: — Specialty: Oncology OBJECTIVE: Rare disease BACKGROUND: Plasmacytoid is a rare histological variant of urothelial carcinoma (UC). Since the first reported case of plasmacytoid urothelial carcinoma (PUC), in 1991, only about 100 cases have since been reported, with most cases involving the bladder. Urothelial carcinomas of the upper urinary tract represent only 5% of urothelial cancers. To the best of our knowledge, there has only been 1 reported case of PUC of the ureter. PUC is a highly aggressive disease, with a poor prognosis. We present a rare biopsy-proven case of PUC of the ureter with retroperitoneal metastasis. CASE REPORT: A 60-year-old man came into the hospital with complaints of a 5-day history of generalized abdominal pain, nausea, and vomiting, with no associated urinary symptoms prior to admission. CT demonstrated small bowel obstruction (SBO) and obstructive uropathy due to a right ureteric mass. Exploratory laparotomy, small bowel resection, gastrostomy tube placement, and umbilical hernia repair were all done. Histology and immunohistochemistry were compatible with plasmacytoid variant of urothelial cancer. He underwent a cystouretoscopy and a right ureteral stent placement with a right ureteroscopy. Final CT abdomen/pelvis revealed recurrent SBO before the ileocecal valve, possibly due to carcinomatosis. Ileocecal resection with end ileostomy placement was done. Systemic treatment will begin as an outpatient. CONCLUSIONS: PUC arising from the ureter is rare, and retroperitoneal metastatic disease has not been reported previously. Here, we compare the clinical manifestations of the more common PUC of the bladder with our case. From this we are able to learn more about the disease and its presentation.
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spelling pubmed-58193062018-02-21 Plasmacytoid Urothelial Carcinoma of Ureter with Retroperitoneal Metastasis: A Case Report Jibril, Alexis Stevens, Andrew C. Am J Case Rep Articles Patient: Male, 60 Final Diagnosis: Plasmacytoid urothelial carcinoma of ureter Symptoms: Constipation • epigastric pain • microscopic hematuria • nausea • vomiting Medication: — Clinical Procedure: — Specialty: Oncology OBJECTIVE: Rare disease BACKGROUND: Plasmacytoid is a rare histological variant of urothelial carcinoma (UC). Since the first reported case of plasmacytoid urothelial carcinoma (PUC), in 1991, only about 100 cases have since been reported, with most cases involving the bladder. Urothelial carcinomas of the upper urinary tract represent only 5% of urothelial cancers. To the best of our knowledge, there has only been 1 reported case of PUC of the ureter. PUC is a highly aggressive disease, with a poor prognosis. We present a rare biopsy-proven case of PUC of the ureter with retroperitoneal metastasis. CASE REPORT: A 60-year-old man came into the hospital with complaints of a 5-day history of generalized abdominal pain, nausea, and vomiting, with no associated urinary symptoms prior to admission. CT demonstrated small bowel obstruction (SBO) and obstructive uropathy due to a right ureteric mass. Exploratory laparotomy, small bowel resection, gastrostomy tube placement, and umbilical hernia repair were all done. Histology and immunohistochemistry were compatible with plasmacytoid variant of urothelial cancer. He underwent a cystouretoscopy and a right ureteral stent placement with a right ureteroscopy. Final CT abdomen/pelvis revealed recurrent SBO before the ileocecal valve, possibly due to carcinomatosis. Ileocecal resection with end ileostomy placement was done. Systemic treatment will begin as an outpatient. CONCLUSIONS: PUC arising from the ureter is rare, and retroperitoneal metastatic disease has not been reported previously. Here, we compare the clinical manifestations of the more common PUC of the bladder with our case. From this we are able to learn more about the disease and its presentation. International Scientific Literature, Inc. 2018-02-13 /pmc/articles/PMC5819306/ /pubmed/29434183 http://dx.doi.org/10.12659/AJCR.906679 Text en © Am J Case Rep, 2018 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Articles
Jibril, Alexis
Stevens, Andrew C.
Plasmacytoid Urothelial Carcinoma of Ureter with Retroperitoneal Metastasis: A Case Report
title Plasmacytoid Urothelial Carcinoma of Ureter with Retroperitoneal Metastasis: A Case Report
title_full Plasmacytoid Urothelial Carcinoma of Ureter with Retroperitoneal Metastasis: A Case Report
title_fullStr Plasmacytoid Urothelial Carcinoma of Ureter with Retroperitoneal Metastasis: A Case Report
title_full_unstemmed Plasmacytoid Urothelial Carcinoma of Ureter with Retroperitoneal Metastasis: A Case Report
title_short Plasmacytoid Urothelial Carcinoma of Ureter with Retroperitoneal Metastasis: A Case Report
title_sort plasmacytoid urothelial carcinoma of ureter with retroperitoneal metastasis: a case report
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819306/
https://www.ncbi.nlm.nih.gov/pubmed/29434183
http://dx.doi.org/10.12659/AJCR.906679
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