Targeting protein-loaded CB[8]-mediated supramolecular nanocarriers to cells

Supramolecular amphiphiles, consisting of ternary complexes of cucurbit[8]uril (CB[8]), an alkylated paraquat derivative and a tetraethylene glycol-functionalized azobenzene, self-assemble into vesicles of about 200 nm in diameter. The outer surface of the vesicles was functionalized with cell-targe...

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Detalles Bibliográficos
Autores principales: Cavatorta, Emanuela, Voskuhl, Jens, Wasserberg, Dorothee, Brinkmann, Jenny, Huskens, Jurriaan, Jonkheijm, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819385/
https://www.ncbi.nlm.nih.gov/pubmed/29568508
http://dx.doi.org/10.1039/c7ra10980f
Descripción
Sumario:Supramolecular amphiphiles, consisting of ternary complexes of cucurbit[8]uril (CB[8]), an alkylated paraquat derivative and a tetraethylene glycol-functionalized azobenzene, self-assemble into vesicles of about 200 nm in diameter. The outer surface of the vesicles was functionalized with cell-targeting ligands. These vesicles were employed for loading and delivery of proteins into cells. Supramolecular amphiphile-derived vesicles show great promise as nanocarriers of functional molecules to be transferred into cells.

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