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Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP

The angiopoietin (ANGPT)–TIE2/TEK signaling pathway is essential for blood and lymphatic vascular homeostasis. ANGPT1 is a potent TIE2 activator, whereas ANGPT2 functions as a context-dependent agonist/antagonist. In disease, ANGPT2-mediated inhibition of TIE2 in blood vessels is linked to vascular...

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Detalles Bibliográficos
Autores principales:	Souma, Tomokazu, Thomson, Benjamin R., Heinen, Stefan, Anna Carota, Isabel, Yamaguchi, Shinji, Onay, Tuncer, Liu, Pan, Ghosh, Asish K., Li, Chengjin, Eremina, Vera, Hong, Young-Kwon, Economides, Aris N., Vestweber, Dietmar, Peters, Kevin G., Jin, Jing, Quaggin, Susan E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2018
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819405/ https://www.ncbi.nlm.nih.gov/pubmed/29358379 http://dx.doi.org/10.1073/pnas.1714446115

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