A Hypoglycemia-inducing Giant Borderline Phyllodes Tumor Secreting High-molecular-weight Insulin-Like Growth Factor II: Immunohistochemistry and a Western Blot Analysis

A 50-year-old woman with a large right breast mass was emergently hospitalized for generalized weakness and fatigue. A histological examination of tumor biopsy specimens revealed a phyllodes tumor (PT). She suddenly lost consciousness due to severe hypoglycemia. Non-islet cell tumor hypoglycemia (NI...

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Autores principales: Hikichi, Masahiro, Kiriyama, Yuka, Hayashi, Takanori, Ushimado, Kaori, Kobayashi, Naomi, Urano, Makoto, Kuroda, Makoto, Utsumi, Toshiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820043/
https://www.ncbi.nlm.nih.gov/pubmed/29021486
http://dx.doi.org/10.2169/internalmedicine.9287-17
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author Hikichi, Masahiro
Kiriyama, Yuka
Hayashi, Takanori
Ushimado, Kaori
Kobayashi, Naomi
Urano, Makoto
Kuroda, Makoto
Utsumi, Toshiaki
author_facet Hikichi, Masahiro
Kiriyama, Yuka
Hayashi, Takanori
Ushimado, Kaori
Kobayashi, Naomi
Urano, Makoto
Kuroda, Makoto
Utsumi, Toshiaki
author_sort Hikichi, Masahiro
collection PubMed
description A 50-year-old woman with a large right breast mass was emergently hospitalized for generalized weakness and fatigue. A histological examination of tumor biopsy specimens revealed a phyllodes tumor (PT). She suddenly lost consciousness due to severe hypoglycemia. Non-islet cell tumor hypoglycemia (NICTH) due to the PT was suspected. The tumor was emergently resected. A histological examination revealed a borderline PT. The patient recovered from the hypoglycemic episode. High-molecular-weight insulin-like growth factor II was detected in serum that had been collected preoperatively and in the tumor tissue, but not in serum that had been collected postoperatively. We herein present a case of a borderline PT with NICTH.
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spelling pubmed-58200432018-02-22 A Hypoglycemia-inducing Giant Borderline Phyllodes Tumor Secreting High-molecular-weight Insulin-Like Growth Factor II: Immunohistochemistry and a Western Blot Analysis Hikichi, Masahiro Kiriyama, Yuka Hayashi, Takanori Ushimado, Kaori Kobayashi, Naomi Urano, Makoto Kuroda, Makoto Utsumi, Toshiaki Intern Med Case Report A 50-year-old woman with a large right breast mass was emergently hospitalized for generalized weakness and fatigue. A histological examination of tumor biopsy specimens revealed a phyllodes tumor (PT). She suddenly lost consciousness due to severe hypoglycemia. Non-islet cell tumor hypoglycemia (NICTH) due to the PT was suspected. The tumor was emergently resected. A histological examination revealed a borderline PT. The patient recovered from the hypoglycemic episode. High-molecular-weight insulin-like growth factor II was detected in serum that had been collected preoperatively and in the tumor tissue, but not in serum that had been collected postoperatively. We herein present a case of a borderline PT with NICTH. The Japanese Society of Internal Medicine 2017-10-11 2018-01-15 /pmc/articles/PMC5820043/ /pubmed/29021486 http://dx.doi.org/10.2169/internalmedicine.9287-17 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Hikichi, Masahiro
Kiriyama, Yuka
Hayashi, Takanori
Ushimado, Kaori
Kobayashi, Naomi
Urano, Makoto
Kuroda, Makoto
Utsumi, Toshiaki
A Hypoglycemia-inducing Giant Borderline Phyllodes Tumor Secreting High-molecular-weight Insulin-Like Growth Factor II: Immunohistochemistry and a Western Blot Analysis
title A Hypoglycemia-inducing Giant Borderline Phyllodes Tumor Secreting High-molecular-weight Insulin-Like Growth Factor II: Immunohistochemistry and a Western Blot Analysis
title_full A Hypoglycemia-inducing Giant Borderline Phyllodes Tumor Secreting High-molecular-weight Insulin-Like Growth Factor II: Immunohistochemistry and a Western Blot Analysis
title_fullStr A Hypoglycemia-inducing Giant Borderline Phyllodes Tumor Secreting High-molecular-weight Insulin-Like Growth Factor II: Immunohistochemistry and a Western Blot Analysis
title_full_unstemmed A Hypoglycemia-inducing Giant Borderline Phyllodes Tumor Secreting High-molecular-weight Insulin-Like Growth Factor II: Immunohistochemistry and a Western Blot Analysis
title_short A Hypoglycemia-inducing Giant Borderline Phyllodes Tumor Secreting High-molecular-weight Insulin-Like Growth Factor II: Immunohistochemistry and a Western Blot Analysis
title_sort hypoglycemia-inducing giant borderline phyllodes tumor secreting high-molecular-weight insulin-like growth factor ii: immunohistochemistry and a western blot analysis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820043/
https://www.ncbi.nlm.nih.gov/pubmed/29021486
http://dx.doi.org/10.2169/internalmedicine.9287-17
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