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The mushroom body D1 dopamine receptor controls innate courtship drive

Mating is critical for species survival and is profoundly regulated by neuromodulators and neurohormones to accommodate internal states and external factors. To identify the underlying neuromodulatory mechanisms, we investigated the roles of dopamine receptors in various aspects of courtship behavio...

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Autores principales: Lim, J., Fernandez, A. I., Hinojos, S. J., Aranda, G. P., James, J., Seong, C.‐S., Han, K.‐A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820115/
https://www.ncbi.nlm.nih.gov/pubmed/28902472
http://dx.doi.org/10.1111/gbb.12425
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author Lim, J.
Fernandez, A. I.
Hinojos, S. J.
Aranda, G. P.
James, J.
Seong, C.‐S.
Han, K.‐A.
author_facet Lim, J.
Fernandez, A. I.
Hinojos, S. J.
Aranda, G. P.
James, J.
Seong, C.‐S.
Han, K.‐A.
author_sort Lim, J.
collection PubMed
description Mating is critical for species survival and is profoundly regulated by neuromodulators and neurohormones to accommodate internal states and external factors. To identify the underlying neuromodulatory mechanisms, we investigated the roles of dopamine receptors in various aspects of courtship behavior in Drosophila. Here, we report that the D1 dopamine receptor dDA1 regulates courtship drive in naïve males. The wild‐type naïve males actively courted females regardless their appearance or mating status. On the contrary, the dDA1 mutant (dumb) males exhibited substantially reduced courtship toward less appealing females including decapitated, leg‐less and mated females. The dumb male's reduced courtship activity was due to delay in courtship initiation and prolonged intervals between courtship bouts. The dampened courtship drive of dumb males was rescued by reinstated dDA1 expression in the mushroom body α/β and γ neurons but not α/β or γ neurons alone, which is distinct from the previously characterized dDA1 functions in experience‐dependent courtship or other learning and memory processes. We also found that the dopamine receptors dDA1, DAMB and dD2R are dispensable for associative memory formation and short‐term memory of conditioned courtship, thus courtship motivation and associative courtship learning and memory are regulated by distinct neuromodulatory mechanisms. Taken together, our study narrows the gap in the knowledge of the mechanism that dopamine regulates male courtship behavior.
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spelling pubmed-58201152018-03-12 The mushroom body D1 dopamine receptor controls innate courtship drive Lim, J. Fernandez, A. I. Hinojos, S. J. Aranda, G. P. James, J. Seong, C.‐S. Han, K.‐A. Genes Brain Behav Original Articles Mating is critical for species survival and is profoundly regulated by neuromodulators and neurohormones to accommodate internal states and external factors. To identify the underlying neuromodulatory mechanisms, we investigated the roles of dopamine receptors in various aspects of courtship behavior in Drosophila. Here, we report that the D1 dopamine receptor dDA1 regulates courtship drive in naïve males. The wild‐type naïve males actively courted females regardless their appearance or mating status. On the contrary, the dDA1 mutant (dumb) males exhibited substantially reduced courtship toward less appealing females including decapitated, leg‐less and mated females. The dumb male's reduced courtship activity was due to delay in courtship initiation and prolonged intervals between courtship bouts. The dampened courtship drive of dumb males was rescued by reinstated dDA1 expression in the mushroom body α/β and γ neurons but not α/β or γ neurons alone, which is distinct from the previously characterized dDA1 functions in experience‐dependent courtship or other learning and memory processes. We also found that the dopamine receptors dDA1, DAMB and dD2R are dispensable for associative memory formation and short‐term memory of conditioned courtship, thus courtship motivation and associative courtship learning and memory are regulated by distinct neuromodulatory mechanisms. Taken together, our study narrows the gap in the knowledge of the mechanism that dopamine regulates male courtship behavior. Blackwell Publishing Ltd 2017-10-09 2018-02 /pmc/articles/PMC5820115/ /pubmed/28902472 http://dx.doi.org/10.1111/gbb.12425 Text en © 2017 The Authors. Genes, Brain and Behavior published by International Behavioural and Neural Genetics Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Lim, J.
Fernandez, A. I.
Hinojos, S. J.
Aranda, G. P.
James, J.
Seong, C.‐S.
Han, K.‐A.
The mushroom body D1 dopamine receptor controls innate courtship drive
title The mushroom body D1 dopamine receptor controls innate courtship drive
title_full The mushroom body D1 dopamine receptor controls innate courtship drive
title_fullStr The mushroom body D1 dopamine receptor controls innate courtship drive
title_full_unstemmed The mushroom body D1 dopamine receptor controls innate courtship drive
title_short The mushroom body D1 dopamine receptor controls innate courtship drive
title_sort mushroom body d1 dopamine receptor controls innate courtship drive
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820115/
https://www.ncbi.nlm.nih.gov/pubmed/28902472
http://dx.doi.org/10.1111/gbb.12425
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