Prostaglandin D(2) amplifies lupus disease through basophil accumulation in lymphoid organs

In systemic lupus erythematosus (SLE), autoantibody production can lead to kidney damage and failure, known as lupus nephritis. Basophils amplify the synthesis of autoantibodies by accumulating in secondary lymphoid organs. Here, we show a role for prostaglandin D(2) (PGD(2)) in the pathophysiology...

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Detalles Bibliográficos
Autores principales: Pellefigues, Christophe, Dema, Barbara, Lamri, Yasmine, Saidoune, Fanny, Chavarot, Nathalie, Lohéac, Charlotte, Pacreau, Emeline, Dussiot, Michael, Bidault, Caroline, Marquet, Florian, Jablonski, Mathieu, Chemouny, Jonathan M., Jouan, Fanny, Dossier, Antoine, Chauveheid, Marie-Paule, Gobert, Delphine, Papo, Thomas, Karasuyama, Hajime, Sacré, Karim, Daugas, Eric, Charles, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820278/
https://www.ncbi.nlm.nih.gov/pubmed/29463843
http://dx.doi.org/10.1038/s41467-018-03129-8

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