Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice

Fractures are a common comorbidity in children with the neural tube defect (NTD) spina bifida. Mutations in the Wnt/planar cell polarity (PCP) pathway contribute to NTDs in humans and mice, but whether this pathway independently determines bone mass is poorly understood. Here, we first confirmed tha...

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Detalles Bibliográficos
Autores principales: Orriss, Isabel R., Lanham, Stuart, Savery, Dawn, Greene, Nicholas D. E., Stanier, Philip, Oreffo, Richard, Copp, Andrew J., Galea, Gabriel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820290/
https://www.ncbi.nlm.nih.gov/pubmed/29463853
http://dx.doi.org/10.1038/s41598-018-21718-x

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