Antigen Loading (e.g., Glutamic Acid Decarboxylase 65) of Tolerogenic DCs (tolDCs) Reduces Their Capacity to Prevent Diabetes in the Non-Obese Diabetes (NOD)-Severe Combined Immunodeficiency Model of Adoptive Cotransfer of Diabetes As Well As in NOD Mice

Tolerogenic DCs (tolDCs) are being researched as a promising intervention strategy also in autoimmune diseases including type 1 diabetes (T1D). T1D is a T-cell-mediated, organ-specific disease with several well-defined and rather specific autoantigens, i.e., proinsulin, insulin, glutamic acid decarb...

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Detalles Bibliográficos
Autores principales: Funda, David P., Goliáš, Jaroslav, Hudcovic, Tomáš, Kozáková, Hana, Špíšek, Radek, Palová-Jelínková, Lenka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820308/
https://www.ncbi.nlm.nih.gov/pubmed/29503651
http://dx.doi.org/10.3389/fimmu.2018.00290

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