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Consequences of VHL Loss on Global DNA Methylome

In clear-cell renal cell carcinoma (ccRCC), loss of von Hippel-Lindau (VHL) tumour suppressor gene and reduced oxygen tension promote stabilisation of hypoxia-inducible factor (HIF) family of transcription factors, which promote changes in the expression of genes that contribute to oncogenesis. Mult...

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Detalles Bibliográficos
Autores principales:	Robinson, Claire M., Lefebvre, Francois, Poon, Betty P., Bousard, Aurelie, Fan, Xiaojun, Lathrop, Mark, Tost, Jorg, Kim, William Y., Riazalhosseini, Yasser, Ohh, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820357/ https://www.ncbi.nlm.nih.gov/pubmed/29463811 http://dx.doi.org/10.1038/s41598-018-21524-5

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