Knockdown of KLK11 reverses oxaliplatin resistance by inhibiting proliferation and activating apoptosis via suppressing the PI3K/AKT signal pathway in colorectal cancer cell

INTRODUCTION: Kallikrein 11 (KLK11) plays a crucial role in drug-resistance to oxaliplatin (L-OHP) in the treatment of metastatic colorectal cancer (mCRC). The study aimed to investigate the role of KLK11 in chemoresistance, and to clarify the mechanism underlying reverse of L-OHP resistance by knoc...

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Detalles Bibliográficos
Autores principales: Zhang, Yiyi, Xu, Zongbin, Sun, Yanwu, Chi, Pan, Lu, Xingrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820466/
https://www.ncbi.nlm.nih.gov/pubmed/29497313
http://dx.doi.org/10.2147/OTT.S151867

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820466/
https://www.ncbi.nlm.nih.gov/pubmed/29497313
http://dx.doi.org/10.2147/OTT.S151867

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