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Imagine the Superiority of Dry Powder Inhalers from Carrier Engineering

Inhalation therapy has strong history of more than 4000 years and it is well recognized around the globe within every culture. In early days, inhalation therapy was designed for treatment of local disorders such as asthma and other pulmonary diseases. Almost all inhalation products composed a simple...

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Autor principal: Mehta, Piyush
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820590/
https://www.ncbi.nlm.nih.gov/pubmed/29568652
http://dx.doi.org/10.1155/2018/5635010
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author Mehta, Piyush
author_facet Mehta, Piyush
author_sort Mehta, Piyush
collection PubMed
description Inhalation therapy has strong history of more than 4000 years and it is well recognized around the globe within every culture. In early days, inhalation therapy was designed for treatment of local disorders such as asthma and other pulmonary diseases. Almost all inhalation products composed a simple formulation of a carrier, usually α-lactose monohydrate orderly mixed with micronized therapeutic agent. Most of these formulations lacked satisfactory pulmonary deposition and dispersion. Thus, various alternative carrier's molecules and powder processing techniques are increasingly investigated to achieve suitable aerodynamic performance. In view of this fact, more suitable and economic alternative carrier's molecules with advanced formulation strategies are discussed in the present review. Furthermore, major advances, challenges, and the future perspective are discussed.
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spelling pubmed-58205902018-03-22 Imagine the Superiority of Dry Powder Inhalers from Carrier Engineering Mehta, Piyush J Drug Deliv Review Article Inhalation therapy has strong history of more than 4000 years and it is well recognized around the globe within every culture. In early days, inhalation therapy was designed for treatment of local disorders such as asthma and other pulmonary diseases. Almost all inhalation products composed a simple formulation of a carrier, usually α-lactose monohydrate orderly mixed with micronized therapeutic agent. Most of these formulations lacked satisfactory pulmonary deposition and dispersion. Thus, various alternative carrier's molecules and powder processing techniques are increasingly investigated to achieve suitable aerodynamic performance. In view of this fact, more suitable and economic alternative carrier's molecules with advanced formulation strategies are discussed in the present review. Furthermore, major advances, challenges, and the future perspective are discussed. Hindawi 2018-01-14 /pmc/articles/PMC5820590/ /pubmed/29568652 http://dx.doi.org/10.1155/2018/5635010 Text en Copyright © 2018 Piyush Mehta. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Mehta, Piyush
Imagine the Superiority of Dry Powder Inhalers from Carrier Engineering
title Imagine the Superiority of Dry Powder Inhalers from Carrier Engineering
title_full Imagine the Superiority of Dry Powder Inhalers from Carrier Engineering
title_fullStr Imagine the Superiority of Dry Powder Inhalers from Carrier Engineering
title_full_unstemmed Imagine the Superiority of Dry Powder Inhalers from Carrier Engineering
title_short Imagine the Superiority of Dry Powder Inhalers from Carrier Engineering
title_sort imagine the superiority of dry powder inhalers from carrier engineering
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820590/
https://www.ncbi.nlm.nih.gov/pubmed/29568652
http://dx.doi.org/10.1155/2018/5635010
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