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Imagine the Superiority of Dry Powder Inhalers from Carrier Engineering
Inhalation therapy has strong history of more than 4000 years and it is well recognized around the globe within every culture. In early days, inhalation therapy was designed for treatment of local disorders such as asthma and other pulmonary diseases. Almost all inhalation products composed a simple...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820590/ https://www.ncbi.nlm.nih.gov/pubmed/29568652 http://dx.doi.org/10.1155/2018/5635010 |
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author | Mehta, Piyush |
author_facet | Mehta, Piyush |
author_sort | Mehta, Piyush |
collection | PubMed |
description | Inhalation therapy has strong history of more than 4000 years and it is well recognized around the globe within every culture. In early days, inhalation therapy was designed for treatment of local disorders such as asthma and other pulmonary diseases. Almost all inhalation products composed a simple formulation of a carrier, usually α-lactose monohydrate orderly mixed with micronized therapeutic agent. Most of these formulations lacked satisfactory pulmonary deposition and dispersion. Thus, various alternative carrier's molecules and powder processing techniques are increasingly investigated to achieve suitable aerodynamic performance. In view of this fact, more suitable and economic alternative carrier's molecules with advanced formulation strategies are discussed in the present review. Furthermore, major advances, challenges, and the future perspective are discussed. |
format | Online Article Text |
id | pubmed-5820590 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-58205902018-03-22 Imagine the Superiority of Dry Powder Inhalers from Carrier Engineering Mehta, Piyush J Drug Deliv Review Article Inhalation therapy has strong history of more than 4000 years and it is well recognized around the globe within every culture. In early days, inhalation therapy was designed for treatment of local disorders such as asthma and other pulmonary diseases. Almost all inhalation products composed a simple formulation of a carrier, usually α-lactose monohydrate orderly mixed with micronized therapeutic agent. Most of these formulations lacked satisfactory pulmonary deposition and dispersion. Thus, various alternative carrier's molecules and powder processing techniques are increasingly investigated to achieve suitable aerodynamic performance. In view of this fact, more suitable and economic alternative carrier's molecules with advanced formulation strategies are discussed in the present review. Furthermore, major advances, challenges, and the future perspective are discussed. Hindawi 2018-01-14 /pmc/articles/PMC5820590/ /pubmed/29568652 http://dx.doi.org/10.1155/2018/5635010 Text en Copyright © 2018 Piyush Mehta. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Mehta, Piyush Imagine the Superiority of Dry Powder Inhalers from Carrier Engineering |
title | Imagine the Superiority of Dry Powder Inhalers from Carrier Engineering |
title_full | Imagine the Superiority of Dry Powder Inhalers from Carrier Engineering |
title_fullStr | Imagine the Superiority of Dry Powder Inhalers from Carrier Engineering |
title_full_unstemmed | Imagine the Superiority of Dry Powder Inhalers from Carrier Engineering |
title_short | Imagine the Superiority of Dry Powder Inhalers from Carrier Engineering |
title_sort | imagine the superiority of dry powder inhalers from carrier engineering |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820590/ https://www.ncbi.nlm.nih.gov/pubmed/29568652 http://dx.doi.org/10.1155/2018/5635010 |
work_keys_str_mv | AT mehtapiyush imaginethesuperiorityofdrypowderinhalersfromcarrierengineering |