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Dermal fibroblasts from patients with Parkinson’s disease have normal GCase activity and autophagy compared to patients with PD and GBA mutations

Background: Recently, the development of Parkinson’s disease (PD) has been linked to a number of genetic risk factors, of which the most common is glucocerebrosidase (GBA) mutations. Methods: We investigated PD and Gaucher Disease (GD) patient derived skin fibroblasts using biochemistry assays. Resu...

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Detalles Bibliográficos
Autores principales:	Collins, Lucy M, Drouin-Ouellet, Janelle, Kuan, Wei-Li, Cox, Timothy, Barker, Roger A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	F1000 Research Limited 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820594/ https://www.ncbi.nlm.nih.gov/pubmed/29527290 http://dx.doi.org/10.12688/f1000research.12090.2

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