Glycyrrhizin Suppresses the Growth of Human NSCLC Cell Line HCC827 by Downregulating HMGB1 Level

Lung cancer has very high mortality and glycyrrhizin was found to significantly inhibit the growth of lung cancer cells in vitro and tissues in mice. However, the detailed inhibitory role of glycyrrhizin in the growth of lung cancer is still unclear. In this study, we first found that glycyrrhizin i...

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Detalles Bibliográficos
Autores principales: Wu, Xiaojin, Wang, Weitao, Chen, Yuanyuan, Liu, Xiangqun, Wang, Jindong, Qin, Xiaobin, Yuan, Dawei, Yu, Tao, Chen, Guangxia, Mi, Yanyan, Mou, Jie, Cui, Jinpeng, Hu, Ankang, E, Yunxiang, Pei, Dongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820661/
https://www.ncbi.nlm.nih.gov/pubmed/29568761
http://dx.doi.org/10.1155/2018/6916797
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author Wu, Xiaojin
Wang, Weitao
Chen, Yuanyuan
Liu, Xiangqun
Wang, Jindong
Qin, Xiaobin
Yuan, Dawei
Yu, Tao
Chen, Guangxia
Mi, Yanyan
Mou, Jie
Cui, Jinpeng
Hu, Ankang
E, Yunxiang
Pei, Dongsheng
author_facet Wu, Xiaojin
Wang, Weitao
Chen, Yuanyuan
Liu, Xiangqun
Wang, Jindong
Qin, Xiaobin
Yuan, Dawei
Yu, Tao
Chen, Guangxia
Mi, Yanyan
Mou, Jie
Cui, Jinpeng
Hu, Ankang
E, Yunxiang
Pei, Dongsheng
author_sort Wu, Xiaojin
collection PubMed
description Lung cancer has very high mortality and glycyrrhizin was found to significantly inhibit the growth of lung cancer cells in vitro and tissues in mice. However, the detailed inhibitory role of glycyrrhizin in the growth of lung cancer is still unclear. In this study, we first found that glycyrrhizin inhibited the growth of lung tumor in PDX mice. And high level of HMGB1 promoted the migration and invasion of lung cancer cells, which was suppressed by glycyrrhizin. Moreover, glycyrrhizin reduced the activity of JAK/STAT signaling pathway, which is the upstream regulator of HMGB1. Therefore, this study revealed a potential mechanism by which glycyrrhizin can inhibit the progression of lung cancer.
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spelling pubmed-58206612018-03-22 Glycyrrhizin Suppresses the Growth of Human NSCLC Cell Line HCC827 by Downregulating HMGB1 Level Wu, Xiaojin Wang, Weitao Chen, Yuanyuan Liu, Xiangqun Wang, Jindong Qin, Xiaobin Yuan, Dawei Yu, Tao Chen, Guangxia Mi, Yanyan Mou, Jie Cui, Jinpeng Hu, Ankang E, Yunxiang Pei, Dongsheng Biomed Res Int Research Article Lung cancer has very high mortality and glycyrrhizin was found to significantly inhibit the growth of lung cancer cells in vitro and tissues in mice. However, the detailed inhibitory role of glycyrrhizin in the growth of lung cancer is still unclear. In this study, we first found that glycyrrhizin inhibited the growth of lung tumor in PDX mice. And high level of HMGB1 promoted the migration and invasion of lung cancer cells, which was suppressed by glycyrrhizin. Moreover, glycyrrhizin reduced the activity of JAK/STAT signaling pathway, which is the upstream regulator of HMGB1. Therefore, this study revealed a potential mechanism by which glycyrrhizin can inhibit the progression of lung cancer. Hindawi 2018-01-15 /pmc/articles/PMC5820661/ /pubmed/29568761 http://dx.doi.org/10.1155/2018/6916797 Text en Copyright © 2018 Xiaojin Wu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wu, Xiaojin
Wang, Weitao
Chen, Yuanyuan
Liu, Xiangqun
Wang, Jindong
Qin, Xiaobin
Yuan, Dawei
Yu, Tao
Chen, Guangxia
Mi, Yanyan
Mou, Jie
Cui, Jinpeng
Hu, Ankang
E, Yunxiang
Pei, Dongsheng
Glycyrrhizin Suppresses the Growth of Human NSCLC Cell Line HCC827 by Downregulating HMGB1 Level
title Glycyrrhizin Suppresses the Growth of Human NSCLC Cell Line HCC827 by Downregulating HMGB1 Level
title_full Glycyrrhizin Suppresses the Growth of Human NSCLC Cell Line HCC827 by Downregulating HMGB1 Level
title_fullStr Glycyrrhizin Suppresses the Growth of Human NSCLC Cell Line HCC827 by Downregulating HMGB1 Level
title_full_unstemmed Glycyrrhizin Suppresses the Growth of Human NSCLC Cell Line HCC827 by Downregulating HMGB1 Level
title_short Glycyrrhizin Suppresses the Growth of Human NSCLC Cell Line HCC827 by Downregulating HMGB1 Level
title_sort glycyrrhizin suppresses the growth of human nsclc cell line hcc827 by downregulating hmgb1 level
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820661/
https://www.ncbi.nlm.nih.gov/pubmed/29568761
http://dx.doi.org/10.1155/2018/6916797
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