The Effect of Dexmedetomidine on Cognitive Function and Protein Expression of Aβ, p-Tau, and PSD95 after Extracorporeal Circulation Operation in Aged Rats

Postoperative cognitive dysfunction (POCD) is a kind of serious neurologic complications and dexmedetomidine has a certain effect on POCD. However, functional mechanism of dexmedetomidine on POCD still remains unclear, so the research mainly studied the effect of dexmedetomidine on cognitive functio...

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Autores principales: Zhang, Ying, Lin, Yong, Liu, Qing, Yuan, Xuemei, Mao, Anqiong, Liu, Yuexin, Li, Qun, Zheng, Jie, Hu, Bin, Yu, Fengxu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820664/
https://www.ncbi.nlm.nih.gov/pubmed/29568750
http://dx.doi.org/10.1155/2018/4014021
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author Zhang, Ying
Lin, Yong
Liu, Qing
Yuan, Xuemei
Mao, Anqiong
Liu, Yuexin
Li, Qun
Zheng, Jie
Hu, Bin
Yu, Fengxu
author_facet Zhang, Ying
Lin, Yong
Liu, Qing
Yuan, Xuemei
Mao, Anqiong
Liu, Yuexin
Li, Qun
Zheng, Jie
Hu, Bin
Yu, Fengxu
author_sort Zhang, Ying
collection PubMed
description Postoperative cognitive dysfunction (POCD) is a kind of serious neurologic complications and dexmedetomidine has a certain effect on POCD. However, functional mechanism of dexmedetomidine on POCD still remains unclear, so the research mainly studied the effect of dexmedetomidine on cognitive function and protein expression in hippocampus and prefrontal cortex cerebrospinal fluid after extracorporeal circulation operation in aged rats. We Found that, compared with POCD group, the cognitive function was improved in POCD + Dex group. We speculate that dexmedetomidine could improve the cognitive function after extracorporeal circulation operation in aged rats and Aβ, p-Tau, and PSD95 protein might have contributed to this favorable outcome.
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spelling pubmed-58206642018-03-22 The Effect of Dexmedetomidine on Cognitive Function and Protein Expression of Aβ, p-Tau, and PSD95 after Extracorporeal Circulation Operation in Aged Rats Zhang, Ying Lin, Yong Liu, Qing Yuan, Xuemei Mao, Anqiong Liu, Yuexin Li, Qun Zheng, Jie Hu, Bin Yu, Fengxu Biomed Res Int Research Article Postoperative cognitive dysfunction (POCD) is a kind of serious neurologic complications and dexmedetomidine has a certain effect on POCD. However, functional mechanism of dexmedetomidine on POCD still remains unclear, so the research mainly studied the effect of dexmedetomidine on cognitive function and protein expression in hippocampus and prefrontal cortex cerebrospinal fluid after extracorporeal circulation operation in aged rats. We Found that, compared with POCD group, the cognitive function was improved in POCD + Dex group. We speculate that dexmedetomidine could improve the cognitive function after extracorporeal circulation operation in aged rats and Aβ, p-Tau, and PSD95 protein might have contributed to this favorable outcome. Hindawi 2018-01-16 /pmc/articles/PMC5820664/ /pubmed/29568750 http://dx.doi.org/10.1155/2018/4014021 Text en Copyright © 2018 Ying Zhang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhang, Ying
Lin, Yong
Liu, Qing
Yuan, Xuemei
Mao, Anqiong
Liu, Yuexin
Li, Qun
Zheng, Jie
Hu, Bin
Yu, Fengxu
The Effect of Dexmedetomidine on Cognitive Function and Protein Expression of Aβ, p-Tau, and PSD95 after Extracorporeal Circulation Operation in Aged Rats
title The Effect of Dexmedetomidine on Cognitive Function and Protein Expression of Aβ, p-Tau, and PSD95 after Extracorporeal Circulation Operation in Aged Rats
title_full The Effect of Dexmedetomidine on Cognitive Function and Protein Expression of Aβ, p-Tau, and PSD95 after Extracorporeal Circulation Operation in Aged Rats
title_fullStr The Effect of Dexmedetomidine on Cognitive Function and Protein Expression of Aβ, p-Tau, and PSD95 after Extracorporeal Circulation Operation in Aged Rats
title_full_unstemmed The Effect of Dexmedetomidine on Cognitive Function and Protein Expression of Aβ, p-Tau, and PSD95 after Extracorporeal Circulation Operation in Aged Rats
title_short The Effect of Dexmedetomidine on Cognitive Function and Protein Expression of Aβ, p-Tau, and PSD95 after Extracorporeal Circulation Operation in Aged Rats
title_sort effect of dexmedetomidine on cognitive function and protein expression of aβ, p-tau, and psd95 after extracorporeal circulation operation in aged rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820664/
https://www.ncbi.nlm.nih.gov/pubmed/29568750
http://dx.doi.org/10.1155/2018/4014021
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