Cargando…

Overexpression of MICAL2, a novel tumor-promoting factor, accelerates tumor progression through regulating cell proliferation and EMT

Molecule interacting with CasL 2 (MICAL2), a microtubule associated monooxygenase, is involved in cell growth, axon guidance, vesicle trafficking and apoptosis. Recent studies have demonstrated that MICAL2 is highly expressed in tumor and accelerates tumor progression and it is deemed to be a novel...

Descripción completa

Detalles Bibliográficos
Autores principales: Cai, Yongqiang, Lu, Jinping, Tang, Faqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820919/
https://www.ncbi.nlm.nih.gov/pubmed/29483957
http://dx.doi.org/10.7150/jca.22355
_version_ 1783301458878267392
author Cai, Yongqiang
Lu, Jinping
Tang, Faqing
author_facet Cai, Yongqiang
Lu, Jinping
Tang, Faqing
author_sort Cai, Yongqiang
collection PubMed
description Molecule interacting with CasL 2 (MICAL2), a microtubule associated monooxygenase, is involved in cell growth, axon guidance, vesicle trafficking and apoptosis. Recent studies have demonstrated that MICAL2 is highly expressed in tumor and accelerates tumor progression and it is deemed to be a novel tumor-promoting factor. MICAL2 overexpression increases cell proliferation to accelerate tumor growth, and MICAL2 also promotes epithelial-mesenchymal transition (EMT)-related proteins to increase cancer cell metastasis. On mechanism, MICAL2 induces EMT by regulating SRF (serum response factor)/MRTF-A (myocardin related transcription factor A) signaling, Semaphorin/Plexin pathway and inducing ROS (Reactive oxygen species) production. In the present review, we introduced MICAL family, expatiated the structure and functions of MICALs, and summarized the mechanisms of MICAL2 involving tumor progression. The challenges and perspectives for MICAL2 in tumor are also discussed.
format Online
Article
Text
id pubmed-5820919
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Ivyspring International Publisher
record_format MEDLINE/PubMed
spelling pubmed-58209192018-02-26 Overexpression of MICAL2, a novel tumor-promoting factor, accelerates tumor progression through regulating cell proliferation and EMT Cai, Yongqiang Lu, Jinping Tang, Faqing J Cancer Review Molecule interacting with CasL 2 (MICAL2), a microtubule associated monooxygenase, is involved in cell growth, axon guidance, vesicle trafficking and apoptosis. Recent studies have demonstrated that MICAL2 is highly expressed in tumor and accelerates tumor progression and it is deemed to be a novel tumor-promoting factor. MICAL2 overexpression increases cell proliferation to accelerate tumor growth, and MICAL2 also promotes epithelial-mesenchymal transition (EMT)-related proteins to increase cancer cell metastasis. On mechanism, MICAL2 induces EMT by regulating SRF (serum response factor)/MRTF-A (myocardin related transcription factor A) signaling, Semaphorin/Plexin pathway and inducing ROS (Reactive oxygen species) production. In the present review, we introduced MICAL family, expatiated the structure and functions of MICALs, and summarized the mechanisms of MICAL2 involving tumor progression. The challenges and perspectives for MICAL2 in tumor are also discussed. Ivyspring International Publisher 2018-01-01 /pmc/articles/PMC5820919/ /pubmed/29483957 http://dx.doi.org/10.7150/jca.22355 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Cai, Yongqiang
Lu, Jinping
Tang, Faqing
Overexpression of MICAL2, a novel tumor-promoting factor, accelerates tumor progression through regulating cell proliferation and EMT
title Overexpression of MICAL2, a novel tumor-promoting factor, accelerates tumor progression through regulating cell proliferation and EMT
title_full Overexpression of MICAL2, a novel tumor-promoting factor, accelerates tumor progression through regulating cell proliferation and EMT
title_fullStr Overexpression of MICAL2, a novel tumor-promoting factor, accelerates tumor progression through regulating cell proliferation and EMT
title_full_unstemmed Overexpression of MICAL2, a novel tumor-promoting factor, accelerates tumor progression through regulating cell proliferation and EMT
title_short Overexpression of MICAL2, a novel tumor-promoting factor, accelerates tumor progression through regulating cell proliferation and EMT
title_sort overexpression of mical2, a novel tumor-promoting factor, accelerates tumor progression through regulating cell proliferation and emt
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820919/
https://www.ncbi.nlm.nih.gov/pubmed/29483957
http://dx.doi.org/10.7150/jca.22355
work_keys_str_mv AT caiyongqiang overexpressionofmical2anoveltumorpromotingfactoracceleratestumorprogressionthroughregulatingcellproliferationandemt
AT lujinping overexpressionofmical2anoveltumorpromotingfactoracceleratestumorprogressionthroughregulatingcellproliferationandemt
AT tangfaqing overexpressionofmical2anoveltumorpromotingfactoracceleratestumorprogressionthroughregulatingcellproliferationandemt