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Analysis of early stage osteonecrosis of the human femoral head and the mechanism of femoral head collapse

We explored the mechanism of early stage osteonecrotic femoral head collapse by analyzing and comparing different regions in human osteonecrotic femoral head samples. Eight osteonecrotic femoral heads (ARCO II-III) were obtained from patients undergoing total hip arthroplasty. Bone structure was obs...

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Detalles Bibliográficos
Autores principales: Wang, Cheng, Meng, Haoye, Wang, Yu, Zhao, Bin, Zhao, Chenyang, Sun, Weijia, Zhu, Yun, Han, Bingxing, Yuan, Xueling, Liu, Ruoxi, Wang, Xin, Wang, Aiyuan, Guo, Quanyi, Peng, Jiang, Lu, Shibi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821037/
https://www.ncbi.nlm.nih.gov/pubmed/29483834
http://dx.doi.org/10.7150/ijbs.18334
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author Wang, Cheng
Meng, Haoye
Wang, Yu
Zhao, Bin
Zhao, Chenyang
Sun, Weijia
Zhu, Yun
Han, Bingxing
Yuan, Xueling
Liu, Ruoxi
Wang, Xin
Wang, Aiyuan
Guo, Quanyi
Peng, Jiang
Lu, Shibi
author_facet Wang, Cheng
Meng, Haoye
Wang, Yu
Zhao, Bin
Zhao, Chenyang
Sun, Weijia
Zhu, Yun
Han, Bingxing
Yuan, Xueling
Liu, Ruoxi
Wang, Xin
Wang, Aiyuan
Guo, Quanyi
Peng, Jiang
Lu, Shibi
author_sort Wang, Cheng
collection PubMed
description We explored the mechanism of early stage osteonecrotic femoral head collapse by analyzing and comparing different regions in human osteonecrotic femoral head samples. Eight osteonecrotic femoral heads (ARCO II-III) were obtained from patients undergoing total hip arthroplasty. Bone structure was observed and evaluated by micro-computed tomography (CT) scans and pathology. Osteoblast and osteoclast activities were detected by tartrate-resistant acid phosphatase, alkaline phosphatase, and immunofluorescent staining. Some trabeculae had microfractures in the subchondral bone and necrotic region, which had lower bone mineral density, as well as trabecular thickness and number, but greater osteoclast activity. A sclerotic band had already appeared in certain samples which had greater trabecular thickness and number, bone mineral density, and osteoblast activity. The appearance of the femoral head did not change significantly in the early stage of osteonecrosis of the femoral head. However, osteoblast and osteoclast activities had already changed in different regions of the osteonecrotic femoral head, which may lead to eventual collapse of the femoral head. Therefore, osteonecrosis of the femoral head must be treated during the early stage. In addition, osteoblast activity should be promoted and osteoclast activity inhibited as early as possible to prevent collapse of an osteonecrotic femoral head.
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spelling pubmed-58210372018-02-26 Analysis of early stage osteonecrosis of the human femoral head and the mechanism of femoral head collapse Wang, Cheng Meng, Haoye Wang, Yu Zhao, Bin Zhao, Chenyang Sun, Weijia Zhu, Yun Han, Bingxing Yuan, Xueling Liu, Ruoxi Wang, Xin Wang, Aiyuan Guo, Quanyi Peng, Jiang Lu, Shibi Int J Biol Sci Research Paper We explored the mechanism of early stage osteonecrotic femoral head collapse by analyzing and comparing different regions in human osteonecrotic femoral head samples. Eight osteonecrotic femoral heads (ARCO II-III) were obtained from patients undergoing total hip arthroplasty. Bone structure was observed and evaluated by micro-computed tomography (CT) scans and pathology. Osteoblast and osteoclast activities were detected by tartrate-resistant acid phosphatase, alkaline phosphatase, and immunofluorescent staining. Some trabeculae had microfractures in the subchondral bone and necrotic region, which had lower bone mineral density, as well as trabecular thickness and number, but greater osteoclast activity. A sclerotic band had already appeared in certain samples which had greater trabecular thickness and number, bone mineral density, and osteoblast activity. The appearance of the femoral head did not change significantly in the early stage of osteonecrosis of the femoral head. However, osteoblast and osteoclast activities had already changed in different regions of the osteonecrotic femoral head, which may lead to eventual collapse of the femoral head. Therefore, osteonecrosis of the femoral head must be treated during the early stage. In addition, osteoblast activity should be promoted and osteoclast activity inhibited as early as possible to prevent collapse of an osteonecrotic femoral head. Ivyspring International Publisher 2018-01-14 /pmc/articles/PMC5821037/ /pubmed/29483834 http://dx.doi.org/10.7150/ijbs.18334 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Wang, Cheng
Meng, Haoye
Wang, Yu
Zhao, Bin
Zhao, Chenyang
Sun, Weijia
Zhu, Yun
Han, Bingxing
Yuan, Xueling
Liu, Ruoxi
Wang, Xin
Wang, Aiyuan
Guo, Quanyi
Peng, Jiang
Lu, Shibi
Analysis of early stage osteonecrosis of the human femoral head and the mechanism of femoral head collapse
title Analysis of early stage osteonecrosis of the human femoral head and the mechanism of femoral head collapse
title_full Analysis of early stage osteonecrosis of the human femoral head and the mechanism of femoral head collapse
title_fullStr Analysis of early stage osteonecrosis of the human femoral head and the mechanism of femoral head collapse
title_full_unstemmed Analysis of early stage osteonecrosis of the human femoral head and the mechanism of femoral head collapse
title_short Analysis of early stage osteonecrosis of the human femoral head and the mechanism of femoral head collapse
title_sort analysis of early stage osteonecrosis of the human femoral head and the mechanism of femoral head collapse
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821037/
https://www.ncbi.nlm.nih.gov/pubmed/29483834
http://dx.doi.org/10.7150/ijbs.18334
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