Angiotensin 1-7 Overexpression Mediated by a Capsid-optimized AAV8 Vector Leads to Significant Growth Inhibition of Hepatocellular Carcinoma In vivo

Background: Angiotensin-(1-7) [Ang-(1-7)] has been identified to inhibit the growth of many types of tumor cells both in vitro and in vivo. However, the rapid degradation of Ang-(1-7) in vivo limits its clinical application. Adeno-associated virus (AAV) serotype-8 is a remarkable vector for long-ter...

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Detalles Bibliográficos
Autores principales: Mao, Yingying, Pei, Nana, Chen, Xinglu, Chen, Huiying, Yan, Renhe, Bai, Na, Li, Andrew, Li, Jinlong, Zhang, Yanling, Du, Hongyan, Chen, Baihong, Sumners, Colin, Wang, Xuejun, Wang, Shengqi, Li, Hongwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821049/
https://www.ncbi.nlm.nih.gov/pubmed/29483825
http://dx.doi.org/10.7150/ijbs.22235

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