Cargando…

The ColM Family, Polymorphic Toxins Breaching the Bacterial Cell Wall

Bacteria host an arsenal of antagonism-mediating molecules to combat for ecologic space. Bacteriocins represent a pivotal group of secreted antibacterial peptides and proteins assisting in this fight, mainly eliminating relatives. Colicin M, a model for peptidoglycan-interfering bacteriocins in Gram...

Descripción completa

Detalles Bibliográficos
Autores principales: Ghequire, Maarten G. K., Buchanan, Susan K., De Mot, René
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821083/
https://www.ncbi.nlm.nih.gov/pubmed/29440573
http://dx.doi.org/10.1128/mBio.02267-17
_version_ 1783301476459741184
author Ghequire, Maarten G. K.
Buchanan, Susan K.
De Mot, René
author_facet Ghequire, Maarten G. K.
Buchanan, Susan K.
De Mot, René
author_sort Ghequire, Maarten G. K.
collection PubMed
description Bacteria host an arsenal of antagonism-mediating molecules to combat for ecologic space. Bacteriocins represent a pivotal group of secreted antibacterial peptides and proteins assisting in this fight, mainly eliminating relatives. Colicin M, a model for peptidoglycan-interfering bacteriocins in Gram-negative bacteria, appears to be part of a set of polymorphic toxins equipped with such a catalytic domain (ColM) targeting lipid II. Diversifying recombination has enabled parasitism of different receptors and has also given rise to hybrid bacteriocins in which ColM is associated with another toxin module. Remarkably, ColM toxins have recruited a diverse array of immunity partners, comprising cytoplasmic membrane-associated proteins with different topologies. Together, these findings suggest that different immunity mechanisms have evolved for ColM, in contrast to bacteriocins with nuclease activities.
format Online
Article
Text
id pubmed-5821083
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher American Society for Microbiology
record_format MEDLINE/PubMed
spelling pubmed-58210832018-03-05 The ColM Family, Polymorphic Toxins Breaching the Bacterial Cell Wall Ghequire, Maarten G. K. Buchanan, Susan K. De Mot, René mBio Perspective Bacteria host an arsenal of antagonism-mediating molecules to combat for ecologic space. Bacteriocins represent a pivotal group of secreted antibacterial peptides and proteins assisting in this fight, mainly eliminating relatives. Colicin M, a model for peptidoglycan-interfering bacteriocins in Gram-negative bacteria, appears to be part of a set of polymorphic toxins equipped with such a catalytic domain (ColM) targeting lipid II. Diversifying recombination has enabled parasitism of different receptors and has also given rise to hybrid bacteriocins in which ColM is associated with another toxin module. Remarkably, ColM toxins have recruited a diverse array of immunity partners, comprising cytoplasmic membrane-associated proteins with different topologies. Together, these findings suggest that different immunity mechanisms have evolved for ColM, in contrast to bacteriocins with nuclease activities. American Society for Microbiology 2018-02-13 /pmc/articles/PMC5821083/ /pubmed/29440573 http://dx.doi.org/10.1128/mBio.02267-17 Text en Copyright © 2018 Ghequire et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Perspective
Ghequire, Maarten G. K.
Buchanan, Susan K.
De Mot, René
The ColM Family, Polymorphic Toxins Breaching the Bacterial Cell Wall
title The ColM Family, Polymorphic Toxins Breaching the Bacterial Cell Wall
title_full The ColM Family, Polymorphic Toxins Breaching the Bacterial Cell Wall
title_fullStr The ColM Family, Polymorphic Toxins Breaching the Bacterial Cell Wall
title_full_unstemmed The ColM Family, Polymorphic Toxins Breaching the Bacterial Cell Wall
title_short The ColM Family, Polymorphic Toxins Breaching the Bacterial Cell Wall
title_sort colm family, polymorphic toxins breaching the bacterial cell wall
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821083/
https://www.ncbi.nlm.nih.gov/pubmed/29440573
http://dx.doi.org/10.1128/mBio.02267-17
work_keys_str_mv AT ghequiremaartengk thecolmfamilypolymorphictoxinsbreachingthebacterialcellwall
AT buchanansusank thecolmfamilypolymorphictoxinsbreachingthebacterialcellwall
AT demotrene thecolmfamilypolymorphictoxinsbreachingthebacterialcellwall
AT ghequiremaartengk colmfamilypolymorphictoxinsbreachingthebacterialcellwall
AT buchanansusank colmfamilypolymorphictoxinsbreachingthebacterialcellwall
AT demotrene colmfamilypolymorphictoxinsbreachingthebacterialcellwall