Mutant p53(R270H) drives altered metabolism and increased invasion in pancreatic ductal adenocarcinoma

Pancreatic cancer is characterized by nearly universal activating mutations in KRAS. Among other somatic mutations, TP53 is mutated in more than 75% of human pancreatic tumors. Genetically engineered mice have proven instrumental in studies of the contribution of individual genes to carcinogenesis....

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Detalles Bibliográficos
Autores principales: Schofield, Heather K., Zeller, Jörg, Espinoza, Carlos, Halbrook, Christopher J., del Vecchio, Annachiara, Magnuson, Brian, Fabo, Tania, Daylan, Ayse Ece Cali, Kovalenko, Ilya, Lee, Ho-Joon, Yan, Wei, Feng, Ying, Karim, Saadia A., Kremer, Daniel M., Kumar-Sinha, Chandan, Lyssiotis, Costas A., Ljungman, Mats, Morton, Jennifer P., Galbán, Stefanie, Fearon, Eric R., Pasca di Magliano, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821189/
https://www.ncbi.nlm.nih.gov/pubmed/29367463
http://dx.doi.org/10.1172/jci.insight.97422

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