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Is there relationship between epicardial fat and cardiovascular parameters in incident kidney transplant patients? A post-hoc analysis
BACKGROUND: Epicardial fat (EF) has been related to increased cardiovascular risk in chronic kidney disease patients. Kidney transplantation is associated with weight gain, especially within the first 12 months. Recently an association between EF and left ventricular mass (LVM) has been suggested in...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821310/ https://www.ncbi.nlm.nih.gov/pubmed/29466361 http://dx.doi.org/10.1371/journal.pone.0191009 |
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author | Yazbek, Daniel Constantino Carvalho, Aluizio Barbosa Barros, Cinara Sa Medina Pestana, Jose Osmar Rochitte, Carlos Eduardo dos Santos Filho, Raul Dias Canziani, Maria Eugênia F. |
author_facet | Yazbek, Daniel Constantino Carvalho, Aluizio Barbosa Barros, Cinara Sa Medina Pestana, Jose Osmar Rochitte, Carlos Eduardo dos Santos Filho, Raul Dias Canziani, Maria Eugênia F. |
author_sort | Yazbek, Daniel Constantino |
collection | PubMed |
description | BACKGROUND: Epicardial fat (EF) has been related to increased cardiovascular risk in chronic kidney disease patients. Kidney transplantation is associated with weight gain, especially within the first 12 months. Recently an association between EF and left ventricular mass (LVM) has been suggested in kidney transplant (KTX) recipients. OBJECTIVE: Evaluate the EF in KTX recipients and its association with cardiovascular parameters in a 12-month follow-up study. METHODS: EF volume was determined using thoracic computed tomography. The EF progressor group (EF gain) was defined by any increment in EF after 12 months. LVM and LVM index were calculated by echocardiography. RESULTS: Ninety-eight incident KTX patients [57% men, 41.2 ± 10.1 years, mean dialysis time prior to transplant of 24 (11–60) months] were analyzed. At baseline and after 12 months, EF was 318.6 (275.2–392.6) ml and 329.5 (271.7–384.8) ml, respectively (p = 0.03). When compared to patients who EF decreased (n = 33), those with EF gain (n = 65) had a greater increase of body mass index, abdominal circumference and blood glucose. These patients also had a lower reduction of LVM index. However in the multivariate analysis, there was no difference in LVM index change between groups (interaction p = 0.565), even after adjustment for hypertension, glucose and coronary calcium score (interaction p = 0.538). CONCLUSION: The impact of EF gain on ventricular mass after KTX could not be definitely confirmed. Further prospective studies in a large sample of KTX patients should be considered to address a possible causal relationship between EF gain and cardiac hypertrophy in this population. |
format | Online Article Text |
id | pubmed-5821310 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-58213102018-03-02 Is there relationship between epicardial fat and cardiovascular parameters in incident kidney transplant patients? A post-hoc analysis Yazbek, Daniel Constantino Carvalho, Aluizio Barbosa Barros, Cinara Sa Medina Pestana, Jose Osmar Rochitte, Carlos Eduardo dos Santos Filho, Raul Dias Canziani, Maria Eugênia F. PLoS One Research Article BACKGROUND: Epicardial fat (EF) has been related to increased cardiovascular risk in chronic kidney disease patients. Kidney transplantation is associated with weight gain, especially within the first 12 months. Recently an association between EF and left ventricular mass (LVM) has been suggested in kidney transplant (KTX) recipients. OBJECTIVE: Evaluate the EF in KTX recipients and its association with cardiovascular parameters in a 12-month follow-up study. METHODS: EF volume was determined using thoracic computed tomography. The EF progressor group (EF gain) was defined by any increment in EF after 12 months. LVM and LVM index were calculated by echocardiography. RESULTS: Ninety-eight incident KTX patients [57% men, 41.2 ± 10.1 years, mean dialysis time prior to transplant of 24 (11–60) months] were analyzed. At baseline and after 12 months, EF was 318.6 (275.2–392.6) ml and 329.5 (271.7–384.8) ml, respectively (p = 0.03). When compared to patients who EF decreased (n = 33), those with EF gain (n = 65) had a greater increase of body mass index, abdominal circumference and blood glucose. These patients also had a lower reduction of LVM index. However in the multivariate analysis, there was no difference in LVM index change between groups (interaction p = 0.565), even after adjustment for hypertension, glucose and coronary calcium score (interaction p = 0.538). CONCLUSION: The impact of EF gain on ventricular mass after KTX could not be definitely confirmed. Further prospective studies in a large sample of KTX patients should be considered to address a possible causal relationship between EF gain and cardiac hypertrophy in this population. Public Library of Science 2018-02-21 /pmc/articles/PMC5821310/ /pubmed/29466361 http://dx.doi.org/10.1371/journal.pone.0191009 Text en © 2018 Yazbek et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Yazbek, Daniel Constantino Carvalho, Aluizio Barbosa Barros, Cinara Sa Medina Pestana, Jose Osmar Rochitte, Carlos Eduardo dos Santos Filho, Raul Dias Canziani, Maria Eugênia F. Is there relationship between epicardial fat and cardiovascular parameters in incident kidney transplant patients? A post-hoc analysis |
title | Is there relationship between epicardial fat and cardiovascular parameters in incident kidney transplant patients? A post-hoc analysis |
title_full | Is there relationship between epicardial fat and cardiovascular parameters in incident kidney transplant patients? A post-hoc analysis |
title_fullStr | Is there relationship between epicardial fat and cardiovascular parameters in incident kidney transplant patients? A post-hoc analysis |
title_full_unstemmed | Is there relationship between epicardial fat and cardiovascular parameters in incident kidney transplant patients? A post-hoc analysis |
title_short | Is there relationship between epicardial fat and cardiovascular parameters in incident kidney transplant patients? A post-hoc analysis |
title_sort | is there relationship between epicardial fat and cardiovascular parameters in incident kidney transplant patients? a post-hoc analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821310/ https://www.ncbi.nlm.nih.gov/pubmed/29466361 http://dx.doi.org/10.1371/journal.pone.0191009 |
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