MHC-I genotype drives early immune selection of oncogenic mutations

MHC-I exposes the intracellular contents to immune cells for surveillance of cellular health. Due to high genomic variation, individuals' immune systems differ in their ability to expose and eliminate cancer-causing mutations. These personalized immune blind spots create specific oncogenic muta...

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Detalles Bibliográficos
Autores principales: Marty, Rachel, de Prisco, Nicola, Carter, Hannah, Font-Burgada, Joan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821412/
https://www.ncbi.nlm.nih.gov/pubmed/29487895
http://dx.doi.org/10.1080/23723556.2017.1409863
Descripción
Sumario:MHC-I exposes the intracellular contents to immune cells for surveillance of cellular health. Due to high genomic variation, individuals' immune systems differ in their ability to expose and eliminate cancer-causing mutations. These personalized immune blind spots create specific oncogenic mutation predispositions within patients and influence their prevalence across populations.

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