MHC-I genotype drives early immune selection of oncogenic mutations

MHC-I exposes the intracellular contents to immune cells for surveillance of cellular health. Due to high genomic variation, individuals' immune systems differ in their ability to expose and eliminate cancer-causing mutations. These personalized immune blind spots create specific oncogenic muta...

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Detalles Bibliográficos
Autores principales: Marty, Rachel, de Prisco, Nicola, Carter, Hannah, Font-Burgada, Joan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821412/
https://www.ncbi.nlm.nih.gov/pubmed/29487895
http://dx.doi.org/10.1080/23723556.2017.1409863
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author Marty, Rachel
de Prisco, Nicola
Carter, Hannah
Font-Burgada, Joan
author_facet Marty, Rachel
de Prisco, Nicola
Carter, Hannah
Font-Burgada, Joan
author_sort Marty, Rachel
collection PubMed
description MHC-I exposes the intracellular contents to immune cells for surveillance of cellular health. Due to high genomic variation, individuals' immune systems differ in their ability to expose and eliminate cancer-causing mutations. These personalized immune blind spots create specific oncogenic mutation predispositions within patients and influence their prevalence across populations.
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spelling pubmed-58214122019-01-25 MHC-I genotype drives early immune selection of oncogenic mutations Marty, Rachel de Prisco, Nicola Carter, Hannah Font-Burgada, Joan Mol Cell Oncol Author's Views MHC-I exposes the intracellular contents to immune cells for surveillance of cellular health. Due to high genomic variation, individuals' immune systems differ in their ability to expose and eliminate cancer-causing mutations. These personalized immune blind spots create specific oncogenic mutation predispositions within patients and influence their prevalence across populations. Taylor & Francis 2018-01-25 /pmc/articles/PMC5821412/ /pubmed/29487895 http://dx.doi.org/10.1080/23723556.2017.1409863 Text en © 2018 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Marty, Rachel
de Prisco, Nicola
Carter, Hannah
Font-Burgada, Joan
MHC-I genotype drives early immune selection of oncogenic mutations
title MHC-I genotype drives early immune selection of oncogenic mutations
title_full MHC-I genotype drives early immune selection of oncogenic mutations
title_fullStr MHC-I genotype drives early immune selection of oncogenic mutations
title_full_unstemmed MHC-I genotype drives early immune selection of oncogenic mutations
title_short MHC-I genotype drives early immune selection of oncogenic mutations
title_sort mhc-i genotype drives early immune selection of oncogenic mutations
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821412/
https://www.ncbi.nlm.nih.gov/pubmed/29487895
http://dx.doi.org/10.1080/23723556.2017.1409863
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AT fontburgadajoan mhcigenotypedrivesearlyimmuneselectionofoncogenicmutations

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