A path from melanocyte stem cells to cutaneous melanoma illuminated by UVB

The relationship between melanocyte stem cells (MCSCs) and melanoma has been unclear. We recently demonstrated that melanoma-prone MCSCs are able to initiate cutaneous melanoma following stem cell activation through ultraviolet-B (UVB) exposure or natural stem cell cycling. Conversely, MCSC quiescen...

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Detalles Bibliográficos
Autores principales: Moon, Hyeongsun, White, Andrew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Author's Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821417/
https://www.ncbi.nlm.nih.gov/pubmed/29487896
http://dx.doi.org/10.1080/23723556.2017.1409864
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author Moon, Hyeongsun
White, Andrew C.
author_facet Moon, Hyeongsun
White, Andrew C.
author_sort Moon, Hyeongsun
collection PubMed
description The relationship between melanocyte stem cells (MCSCs) and melanoma has been unclear. We recently demonstrated that melanoma-prone MCSCs are able to initiate cutaneous melanoma following stem cell activation through ultraviolet-B (UVB) exposure or natural stem cell cycling. Conversely, MCSC quiescence is sufficient to suppress tumorigenesis. This provides new insight into the role of environmental factors in tumor initiation from adult stem cells.
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spelling pubmed-58214172019-01-23 A path from melanocyte stem cells to cutaneous melanoma illuminated by UVB Moon, Hyeongsun White, Andrew C. Mol Cell Oncol Author's Views The relationship between melanocyte stem cells (MCSCs) and melanoma has been unclear. We recently demonstrated that melanoma-prone MCSCs are able to initiate cutaneous melanoma following stem cell activation through ultraviolet-B (UVB) exposure or natural stem cell cycling. Conversely, MCSC quiescence is sufficient to suppress tumorigenesis. This provides new insight into the role of environmental factors in tumor initiation from adult stem cells. Taylor & Francis 2018-01-23 /pmc/articles/PMC5821417/ /pubmed/29487896 http://dx.doi.org/10.1080/23723556.2017.1409864 Text en © 2018 The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author's Views
Moon, Hyeongsun
White, Andrew C.
A path from melanocyte stem cells to cutaneous melanoma illuminated by UVB
title A path from melanocyte stem cells to cutaneous melanoma illuminated by UVB
title_full A path from melanocyte stem cells to cutaneous melanoma illuminated by UVB
title_fullStr A path from melanocyte stem cells to cutaneous melanoma illuminated by UVB
title_full_unstemmed A path from melanocyte stem cells to cutaneous melanoma illuminated by UVB
title_short A path from melanocyte stem cells to cutaneous melanoma illuminated by UVB
title_sort path from melanocyte stem cells to cutaneous melanoma illuminated by uvb
topic Author's Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821417/
https://www.ncbi.nlm.nih.gov/pubmed/29487896
http://dx.doi.org/10.1080/23723556.2017.1409864
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