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Differentiated embryo chondrocyte plays a crucial role in DNA damage response via transcriptional regulation under hypoxic conditions
Tumor hypoxia contributes to a biologically aggressive phenotype and therapeutic resistance. Recent studies have revealed that hypoxia reduces expression of several DNA damage recognition and repair (DRR) genes via both hypoxia-inducible factor (HIF)-independent and -dependent pathways, and this ind...
Autores principales: | Nakamura, Hideaki, Bono, Hidemasa, Hiyama, Keiko, Kawamoto, Takeshi, Kato, Yukio, Nakanishi, Takeshi, Nishiyama, Masahiko, Hiyama, Eiso, Hirohashi, Nobuyuki, Sueoka, Eisaburo, Poellinger, Lorenz, Tanimoto, Keiji |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821451/ https://www.ncbi.nlm.nih.gov/pubmed/29466367 http://dx.doi.org/10.1371/journal.pone.0192136 |
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