The ancestral retinoic acid receptor was a low-affinity sensor triggering neuronal differentiation

Retinoic acid (RA) is an important intercellular signaling molecule in vertebrate development, with a well-established role in the regulation of hox genes during hindbrain patterning and in neurogenesis. However, the evolutionary origin of the RA signaling pathway remains elusive. To elucidate the e...

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Detalles Bibliográficos
Autores principales: Handberg-Thorsager, Mette, Gutierrez-Mazariegos, Juliana, Arold, Stefan T., Kumar Nadendla, Eswar, Bertucci, Paola Y., Germain, Pierre, Tomançak, Pavel, Pierzchalski, Keely, Jones, Jace W., Albalat, Ricard, Kane, Maureen A., Bourguet, William, Laudet, Vincent, Arendt, Detlev, Schubert, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821490/
https://www.ncbi.nlm.nih.gov/pubmed/29492455
http://dx.doi.org/10.1126/sciadv.aao1261

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