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Quantification of 11β-hydroxysteroid dehydrogenase 1 kinetics and pharmacodynamic effects of inhibitors in brain using mass spectrometry imaging and stable-isotope tracers in mice

11β-Hydroxysteroid dehydrogenase 1 (11β-HSD1; EC 1.1.1.146) generates active glucocorticoid hormones. Small molecule inhibitors have been developed to target 11β-HSD1 for the treatment of dementia; these must enter brain subregions, such as the hippocampus, to be effective. We previously reported ma...

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Detalles Bibliográficos
Autores principales:	Cobice, D.F., Livingstone, D.E.W., McBride, A., MacKay, C.L., Walker, B.R., Webster, S.P., Andrew, R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821700/ https://www.ncbi.nlm.nih.gov/pubmed/29248595 http://dx.doi.org/10.1016/j.bcp.2017.12.013

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