PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation

PARP1 regulates the repair of DNA single-strand breaks generated directly, or during base excision repair (BER). However, the role of PARP2 in these and other repair mechanisms is unknown. Here, we report a requirement for PARP2 in stabilising replication forks that encounter BER intermediates throu...

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Detalles Bibliográficos
Autores principales: Ronson, George E., Piberger, Ann Liza, Higgs, Martin R., Olsen, Anna L., Stewart, Grant S., McHugh, Peter J., Petermann, Eva, Lakin, Nicholas D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821833/
https://www.ncbi.nlm.nih.gov/pubmed/29467415
http://dx.doi.org/10.1038/s41467-018-03159-2

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